Prosthetic valve thrombosis is a life-threatening complication that is seen most commonly in patients with left-sided prosthetic valves. However, mechanical tricuspid valves carry the highest risk of thrombosis of any cardiac valve. Thrombolysis has been performed successfully in right-sided prosthetic valve thrombosis and has been recommended as the first-line treatment in these patients. Alth...

Abstract Background Venous thoracic outlet syndrome resulting in the upper limb deep venous thrombosis is known as Paget–Schroetter or effort thrombosis. A general treatment algorithm includes catheter-directed thrombolysis followed by surgical decompression. There are limited data regarding endovascular of rethrombosis presenting early after surgery. Case presentation Two cases successfully tr...

Objectives: To determine the outcome of thrombolysis in patients with Prosthetic valve thrombosis (PVT). Design: A retrospective descriptive study. Setting: The intensive care unit of the National Cardiothoracic centre, Korle-bu Teaching Hospital, Accra, Ghana. Subjects: 5 consecutive patients who were thrombolysed for 6 episodes of prosthetic valve thrombosis. Patients and Methods : Over a 3ye...

Acute myocardial infarction (AMI) evolves as a time-dependent wave front of ischemia when the abrupt rupture of an unstable fatty plaque initiates coronary thrombosis. The prospect of salvaging potentially viable myocardial tissue has led to the development of reperfusion strategies using thrombolytic agents. The efficacy of thrombolytic therapy is determined in large measure by the speed with ...

A 57-year-old man with past medical history of asthma was transferred from an outside hospital for evaluation of cardiac mass where he was treated for extensive right lower extremity iliofemoral deep venous thrombosis with catheterdirected thrombolytic therapy and thrombectomy. Due to concern of compressive physiology at the site of thrombosis, 2 overlapping self-expanding WALLSTENT endoprosthe...

Thrombosis of a mechanical prosthetic valve is a serious and fortunately it is a rare complication of cardiac valve replacement. We present a case of prosthetic mechanical valve On-X 31/33 mm thrombosis thrombus size 8 x 14 mm on a mitral position, which was treated with a successful intravenous thrombolytic therapy of streptokinase infusion over 10 hours repeated twice with no complications.

A young man presented to the emergency room in extremis and deteriorated into a state of pulseless electrical activity. Bedside echocardiography by emergency medicine physicians was crucial to the clinical decision to implement thrombolytic therapy for suspected massive pulmonary embolus.

Computed tomography (CT) is the current standard for time-critical decision-making in stroke patients, informing decisions on thrombolytic therapy with tissue plasminogen activator (tPA), which has a narrow therapeutic index. We aimed to develop a CT-based method to directly visualize cerebrovascular thrombi and guide thrombolytic therapy. Glycol-chitosan-coated gold nanoparticles (GC-AuNPs) we...