Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by recurrent thromboembolic events (arterial or venous) and/or morbidity in pregnancy (fetal loss, premature birth, or recurrent embryonic losses) in the presence of laboratory evidence of antiphospholipid antibodies (aPL). APS is a multisystem disorder. Several lung manifestations may develop in patients with APS in...

The antiphospholipid syndrome is characterized by the presence of antiphospholipid antibodies in plasma of patients with thromboembolic complications. A major problem in defining the syndrome is that serologic assays to detect antiphospholipid antibodies have a low specificity. We recently published a method that specifically detects lupus anticoagulant (LAC) caused by anti– 2-glycoprotein I an...

The antiphospholipid syndrome is characterized by the presence of antiphospholipid antibodies in plasma of patients with thromboembolic complications. A major problem in defining the syndrome is that serologic assays to detect antiphospholipid antibodies have a low specificity. We recently published a method that specifically detects lupus anticoagulant (LAC) caused by anti-beta(2)-glycoprotein...

Effective treatment of arterial thoracic outlet syndrome includes early recognition and timely correction, with sufficient decompression of the thoracic outlet. A 56-year-old female suffered recrudescent right upper extremity ischemia due to thromboembolic event, raising suspicion for arterial thoracic outlet syndrome and prompting further imaging studies for confirmation. Decompression of the ...

Acquired thrombotic and thromboembolic disorders may be presented initially with symptoms and signs of acute ischaemia or organ dysfunction that will lead many of these patients to seek care in the emergency department. We report a case of a 19-year-old female patient who developed catastrophic antiphospholipid syndrome (CAPS syndrome or Asherson syndrome) 6 weeks post stillbirth with an initia...

Pulmonary hypertension is characterized by elevated pulmonary arterial pressure and secondary right ventricular failure. A thromboembolic occlusion of the proximal or distal pulmonary vasculature results in chronic thromboembolic pulmonary hypertension. We report an uncommon case that presented to our hospital with symptoms of dyspnea on exertion over 2 years. The patient had been treated for p...

Venous thromboembolic disease (VTED) can be fatal, particularly in orthopaedic surgical patients.14,15 Clinicians and researchers continue to struggle to define, from a riskbenefit perspective, which subset of foot and ankle patients would benefit from prophylaxis and which treatment is appropriate for a given patient. Efforts have focused on preventing the most common and most dangerous sequel...

Extrinsic compression of the left main coronary artery (LMCA) can occur in patients with an enlarged pulmonary artery trunk secondary to severe pulmonary hypertension (PH). This phenomenon rarely occurs in PH; moreover, few reports have shown that chronic thromboembolic PH can be a triggering factor for this syndrome. Herein, we describe a patient with extrinsic compression of the LMCA with chr...

Antiphospholipid antibody syndrome (APS) is characterized by the development of venous and/or arterial thrombosis and gestational morbidity (recurrent fetal losses) in presence antiphospholipid antibodies. We report case a 38-year-old woman who was diagnosed with primary APS from thromboembolic abnormalities retinal periphery that led to ischemia. The aim this study share physicians medical und...