نتایج جستجو برای: thp 1 پانیسیک اسید

تعداد نتایج: 2765370  

Journal: :Blood 2002
Florence Sabatier Veronique Roux Francine Anfosso Laurence Camoin José Sampol Françoise Dignat-George

In the present study we investigated whether endothelial microparticles (EMPs) can bind to monocytic THP-1 cells and modulate their procoagulant properties. Using flow cytometry, we demonstrated that EMPs express adhesive receptors similar to those expressed by activated endothelial cells. Expression of endothelial antigens by THP-1 cells incubated with EMP was shown by immunoperoxidase stainin...

Journal: :Journal of lipid research 1999
S Matveev D R van der Westhuyzen E J Smart

Scavenger receptor (SR)-BI mediates the selective uptake of high density lipoprotein (HDL) cholesteryl esters and the efflux of free cholesterol. In Chinese hamster ovary (CHO) cells, SR-BI is predominantly associated with caveolae which we have recently demonstrated are the initial loci for membrane transfer of HDL cholesteryl esters. Because cholesterol accumulation in macrophages is a critic...

2002
Florence Sabatier Veronique Roux Francine Anfosso Laurence Camoin José Sampol Françoise Dignat-George

In the present study we investigated whether endothelial microparticles (EMPs) can bind to monocytic THP-1 cells and modulate their procoagulant properties. Using flow cytometry, we demonstrated that EMPs express adhesive receptors similar to those expressed by activated endothelial cells. Expression of endothelial antigens by THP-1 cells incubated with EMP was shown by immunoperoxidase stainin...

2016
Xiang-qing Zhu Wei Lu Yang Chen Xiao-fan Cheng Jia-ying Qiu Yan Xu Ying Sun

Periodontitis is a chronic inflammatory disease induced by bacteria. Exposure of the host to periodontal pathogens and their virulence factors induces a state of hyporesponsiveness to subsequent stimulations, which is termed endotoxin tolerance. The role and mechanism of lipopolysaccharide (LPS)-tolerized monocytes in inflammatory responses in neutrophils are currently unclear. Here, conditione...

Journal: :Blood 1992
R Datta K Imamura S J Goldman A C Dianoux D W Kufe M L Sherman

Macrophage colony-stimulating factor (M-CSF) is required for the proliferation, differentiation, and activation of monocytes. High-affinity receptors for M-CSF are encoded by the c-fms proto-oncogene. In the present study, we show that c-fms transcripts are detectable in human THP-1 myeloid leukemia cells. Furthermore, radiolabeled 125I-M-CSF is rapidly internalized into THP-1 cells and then de...

2015
Hideko Maeda Risa Tanaka Hirokazu Nakayama

The solubility of trihexyphenidyl (Thp) was improved by its combination with β-cyclodextrin (β-CD) and modified β-CDs. The solubility of Thp was found to be increased in the presence of β-CD, hydroxypropyl-β-cyclodextrin (HP-β-CD), methyl-β-cyclodextrin (Me-β-CD) and sulfobutylether-β-cyclodextrin (SBE-β-CD). In particular, the solubility of Thp in conjunction with SBE-β-CD was increased by a f...

2011
ANA CAROLINA ALMEIDA JUSSARA REHDER SILVANA DALGÈ SEVERINO JOSÉ MARTINS-FILHO PETER E. NEWBURGER ANTONIO CONDINO-NETO

The aim of this work was to analyze the effect of Interferon(IFN) and tumor necrosis factor(TNF) on NADPH oxidase activity and gp91-phox gene expression in human colostrum macrophages (CM), peripheral blood monocytes (PBM), and myelomonocytic THP-1 cells. We also investigated the effect of IFNon the release of TNFby these cells. Our results show that under basal culture conditions, CM release m...

Journal: :Evidence-based Complementary and Alternative Medicine 2021

Gouty arthritis is characterized by the deposition of monosodium urate (MSU) within synovial joints and tissues due to increased concentrations. Here, we elucidated role natural compound cichoric acid (CA) on MSU crystal-stimulated inflammatory response. The THP-1-derived macrophages (THP-Ms) were pretreated with CA then stimulated suspensions. protein levels p65 I?B?, activation NF-?B signalin...

2006
Shigeru Tsuchiya Yasuko Kobayashi Yoichi Goto Hidesada Okumura Shingi Nakae Keiya Tada

Suspension cultures of a human monocytic leukemia cell line, THP-1, were treated with 0.16 to 160 nw 12-O-tetradecanoylphorbol-13-acetate (TPA). In an original cell line, THP1-O, cultured again from —80°cryopreservation, more than 80% of the cells adhered to the glass substrate with marked morphological change within 3 hr of TPA treatment. Adherent cells became flat and amoeboid in shape, an...

2006
Shigeru Tsuchiya Yasuko Kobayashi Yoichi Goto Hidesada Okumura Shingi Nakae Tasuke Konno Keiya Tada

Suspension cultures of a human monocytic leukemia cell line, THP-1, were treated with 0.16 to 160 nw 12-O-tetradecanoylphorbol-13-acetate (TPA). In an original cell line, THP1-O, cultured again from —80°cryopreservation, more than 80% of the cells adhered to the glass substrate with marked morphological change within 3 hr of TPA treatment. Adherent cells became flat and amoeboid in shape, an...

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