Indoleamine 2,3-dioxygenase (IDO) metabolizes L-tryptophan to L-kynurenine, promotes immunosuppression, and has been described as a consumer of superoxide. We discovered IDO expression in periaortic fat and tested the hypothesis that periarterial IDO functionally reduces agonist-induced contraction. Our model was the thoracic aorta, abdominal aorta, and superior mesenteric artery of the male Sp...

reports have shown the antioxidant, hypotensive, hypolipidemic and vasodilatory effects of grape (vitis vinifera l.) seed extract. we have recently shown the relaxatory effect of grape leaf extract on rat uterus and reduction of frog heart rate and contractility. the aim of the present study was to investigate the relaxant effect of vitis vinifera leaf hydroalcoholic extract (vlhe) on rat thora...

Young pigs raised on a copper-deficient diet develop severe abnormalities of connective tissue due to defective cross-linking of collagen and elastin. They eventually succumb to anemia and cardiovascular damage, the latter apparently due to the defective connective tissue metabolism. We evaluated the effects of nutritional copper deficiency upon collagen and elastin synthesis using short-term e...

Indications for and experience with placement of endovascular stent-grafts in the thoracic aorta are still evolving. Common pathologic conditions of the thoracic aorta that are amenable to stent placement include penetrating ulcers, aortic dissection, aortic aneurysms, aortic rupture, and congenital abnormalities. Advances in multidetector computed tomography (CT) permit high-quality two-dimens...

introduction melioidosis is a rapidly fatal infectious disease caused by burkholderia pseudomallei, an agent of potential biothreat, endemic in several parts of india. most melioidosis-induced infected aneurysms are located in the abdominal or thoracic aorta. case presentation we reported two unusual cases of melioidosis resulting in pseudoaneurysm of the descending thoracic aorta. in both case...

Background: The aim of this study was to assess geometrical modifications the aneurysmal Thoracic Aorta (TA) after Endovascular Repair (TEVAR) over 3 years follow-up, identify features predicting unfavorable evolution.

Descending thoracic aorta to femoral bypass graft is an alternative procedure for revascularization of the lower extremities to conventional techniques, when the abdominal aorta is complete obstructed. In general, this technique is performed by surgeons, when abdomen is unable to be opened due to the presence of an abdominal infection, fistulas, or hostile abdomen. In this article, we present o...

Aortic aneurysms usually develop in the atherosclerosis prone infrarenal abdominal aorta. To assess the role of atherosclerosis in aortic enlargement, we studied the relation between plaque formation and aortic size in 30 pressure-fixed male cadaver aortas (age 40-95 years, mean age 67 years). Morphometric analysis of transverse sections of the mid-thoracic and the mid-abdominal aortas included...

Background & Aims: Considering increasing incidence of cardiovascular disorders in diabetes mellitus and some evidence on antioxidant and antidiabetic potentials of naringenin, this study was conducted to evaluate the beneficial effects of 6-week administration of naringenin on contractile reactivity of isolated thoracic aorta in diabetic rats. Methods: Male Wistar rats were divided into contro...