We report the photoelectron spectra of the negative ions of 4-thiouracil (4-TU)(-) and 2,4-dithiouracil (2,4-DTU)(-). Both of these spectra are indicative of valence anions, and they are each dominated by a single broad band with vertical detachment energies of 1.05 and 1.4 eV, respectively. Complementary calculations by Dolgounitcheva, Zakrzewski, and Ortiz (see companion paper) are in accord ...

This study aimed to evaluate the effect of adhesive systems based on a thiouracil monomer on bonding to silver-palladium-copper-gold (Ag-Pd-Cu-Au) alloy (Castwell M.C.12). Disk specimens were cast from the alloy and then air-abraded with alumina. The disks were bonded using six bonding systems selected from four primers and three luting materials. Shear bond strengths were determined both befor...

Accurate excited-state quantum chemical calculations on 2-thiouracil, employing large active spaces and up to quadruple-ζ quality basis sets in multistate complete active space perturbation theory calculations, are reported. The results suggest that the main relaxation path for 2-thiouracil after photoexcitation should be S2 → S1 → T2 → T1, and that this relaxation occurs on a subpicosecond tim...

No reports have been published on the possible effects upon rheumatoid arthritis of the thiouracil drugs, which have a potent action on the thyroid and also on the adrenal glands, although several investigators have pointed out certain correlations between disturbances of the thyroid on the one hand, and rheumatoid arthritis on the other, and the study of the adrenal cortex plays a central role...

The ability of 4-thiouracil to strongly absorb UVA radiation and to populate a reactive triplet state in high yield has enabled its use as a versatile photocrosslinker for nearly 50 years. In this contribution, we present a detailed spectroscopic and photochemical investigation of the 2-thiouracil, 4-thiouracil, and 2,4-dithiouracil series in an effort to further advance this chemistry and to s...

The synthesis of 5-cyanomethoxy-2-thiouracil (5b) is described. The acid catalysed ethanolysis of 5b leads to 5-ethoxycarbonylmethoxy-2-thiouracil (5a). Condensations of 5-methoxy-2thiouracil (5) and 5a with the sugar component 7 using the "silyl method" yield peracylated 5-methoxy-2-thiouridine (8) and 5-ethoxycarbonylmethoxy-2-thiouridine (8a), which under treatment with sodium methanolate/me...

We examined the influence of thiouraeil-induecd hypothyroidism imposed at various stages of development upon pituitary growth hormone (OH) concentration. Balb/e-derived mice were mated and fed thionracil, 0.25% in Purina Lab Chow, from the first day of pregnancy until 25 days postpartum, or for shorter periods of time (last % of pregnancy and postpartum, last j/$ of pregnancy and postpartum, or...