Thiosemicarbazones and their metal complexes are compounds that possess antitumor, antibacterial, antifungal and antiviral properties. For the foremost majority of cases the activity of the ligand is greatly enhanced by the presence of a metal ion. The most relevant papers recently published are reviewed with an attempt to find a relationship between common structural features and activity.

The heterocyclization reaction on thiosemicarbazones having the D-galacto, D-gluco and D-manno configuration was studied. We applied two different acetylating conditions, and the reaction products obtained were identified, spectroscopically characterized, and conformationally analyzed. Using experimental data, we discuss a possible mechanistic pathway for heterocyclization and evaluate the infl...

Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii.

REFERENCES 1. W. S. DAVIDSON: .. Evaluation of New Treatments" Lep. Rev. XXIV, 139, 1953. 2. E. GRUNBERG and R. J. SCHNITZER: .. Antagonism of Isoniazid and Strepto­ mycin in Experimental Infection of Mice with M. Tuberculosis H37Rv." America// Rev. of Tubermlosis, Vol. 68. 277. 1953. 3. W. SZYBALSKI and V. BRYSON: .. Conditional Antagonism between Isoniazid and other Antibacterial Agents." Ibi...

Novel quinoline derivatives was designed as anticancer iron chelators. Structurally they combine active moieties of known quinoline and thiosemicarbazone bioeffectors. For the synthetic part of study we applied microvawe assisted techniques MAOS. Resulted compounds exhibited interesting anticancer activities against HCT116 cancer cells.

The time course of phosphorylation of thymidine and the effects of various inhibitors on the phosphorylation of thymidine and on DNA synthesis in Ehrlich ascites car cinoma cells in vitro were studied with a double-isotope labeling method. Hydroxyurea, mitomycin C, cycloheximide, puromycin, 1-0-D-arabinofuranosylcytosine, 5-fluoroorotic aldehyde, and the thiosemicarbazones of 2-phthalimido alip...

A novel thiosemicarbazone from 2-acetonaphthone (represented as acnTSC) has been synthesized and its basic coordination chemistry with zinc(II), cobalt(II), and copper(II) explored. The complexes were characterized by elemental analysis and various spectroscopic techniques and are best formulated as [M(acnTSC)(2)Cl(2)] with the metal likely in an octahedral environment. The anticancer activity ...

The search of new compounds with medicinal applications is promoting important therapeutic advances and generates a new scientific multidisciplinary field where chemistry, pharmacy and biomedicine overlap together with other specialities. Thiosemicarbazones are some of the studied compounds. These sulfur-containing organic substances exhibit an interesting biological activity, which has been st...