both midazolam and thiopental sodium are being used as induction agents and for maintenance of anesthesia. in contrast to other benzodiazepines such as diazepam, midazolam has a rapid onset of action and fast distribution and causes few cardiovascular or respiratory effects. being water soluble, midazolam is also associated with a low incidence of venous irritation. the purpose of this study wa...

Both midazolam and thiopental sodium are being used as induction agents and for maintenance of anesthesia. In contrast to other benzodiazepines such as diazepam, midazolam has a rapid onset of action and fast distribution and causes few cardiovascular or respiratory effects. Being water soluble, midazolam is also associated with a low incidence of venous irritation. The purpose of this stu...

Various issues related to clinical use of medicines remain unclear, and pharmacists are expected establish evidence for appropriate medicines. The present review summarizes our findings from three areas research regarding the in operating room: 1) We evaluated extent extravasation injury due thiopental (2.5 mg/100 μL) propofol (1.0 at macroscopic histopathologic levels a rat model. Thiopental, ...

The methanolic leaf extract of Thuja occidentalis was evaluated for possible sedative activities in mice. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and elevated-plus maze (EPM) tests at 200mg/kg and 400 mg/kg.  The extract decreased the locomotor activity of mice in hole cross, open field and EPM test and showed the remarka...

In Cook v. FDA,1 the US Court of Appeals for the District of Columbia Circuit unanimously affirmed a March 2012 decision by the DC District Court permanently enjoining the Food andDrug Administration (FDA) from permitting the entry of foreign manufactured sodium thiopental (thiopental) into interstate commerce. The decision is a serious setback for the FDA’s use of its enforcement discretion.Co...

Following a single administration of sodium thiopental in high doses (85 mg/kg intraperitoneally), the animals demonstrated absence or weakening reflexes at levels spinal cord, medulla oblongata, bridge and midbrain cerebral cortex over period one day. Other signs included pronounced hypothermia, decrease respiratory rate violation its rhythm, distinct tendency to bradycardia. On days 1-3 after...

BACKGROUND Thiopental sodium and Propofol are two widely-used drugs in the induction of anesthesia in assisted reproductive technology (ART). However, the side effects and outcome of recovery from anesthesia of these drugs on ART have not been identified yet. OBJECTIVE This study aimed at investigating the side effects and hemodynamic effects of using thiopental sodium and propofal as well as...

PURPOSE To determine the efficacy and safety of rectal thiopental sodium as a sedation agent for pediatric imaging. METHODS Four hundred sixty-two infants and children were sedated with rectal thiopental sodium for MR, CT, or nuclear imaging in 1992 and 1993. Patients received screening histories and physical examinations before sedation, and parents gave informed consent. Sedated patients we...

BACKGROUND Emergence agitation (EA) in children after sevoflurane anesthesia is common. The purpose of this study was to compare the incidences of EA between ketamine and thiopental sodium induction in children underwent sevoflurane anesthesia. We also evaluated if a small dose of fentanyl could reduce the incidence of EA. METHODS The patients who were scheduled for strabismus or entropion su...