نتایج جستجو برای: thioguanine

تعداد نتایج: 1272  

Journal: :Clinical science 1988
J R Bronk N Lister M I Shaw

1. The transport of 6-thioguanine and 6-mercaptopurine has been studied with isolated jejunal loops of mouse small intestine. H.p.l.c. was used to identify and quantify the thiopurines and their metabolites in the serosal secretions. 2. When the lumen of the intestinal loops contained either 6-thioguanine or 6-mercaptopurine at a concentration of 1 mmol/l, the concentration of unmetabolized dru...

Journal: :British Journal of Cancer 2009

3D culture 658 4E-BP1 424 5-FU 1846 6-thioguanine 269 7q34 722 A2

Journal: :Cancer research 1961
G A LEPAGE M JONES

Evidence reported earlier, indicating that the tumor-inhibitory properties of 6thioguanine resulted from the incorporation of this guanine analog into the nucleic acids of the tumor, was supported by the following additional findings: (a) susceptible tumors showed maximum response to treatment initiated at any time during the rapidgrowth phase; (b) incorporation of thioguanine into tumor-cell n...

Journal: :Journal of Crohn's & colitis 2010
Nanne K H de Boer Dirk P van Asseldonk Adriaan van Bodegraven

With great interest, we have read the updated ECCO consensus on the treatment of Crohn's disease.1 Being highly interested in research on the clinical use of thiopurines, we feel that several additional commentsmay give opportunity to a more balanced, evidence-based conclusion on the discarded use of 6-thioguanine as an alternative thiopurine. Firstly, the authors state that 6-thioguanine is th...

Journal: :British medical bulletin 2006
Peter Karran

AIMS The thiopurines, azathioprine, 6-mercaptopurine and 6-thioguanine are one of the success stories of chemotherapy. They are effective immunosuppressants and anti-cancer agents and are prescribed increasingly to treat inflammatory diseases. Although their metabolism has been studied in detail, the optimal use of thiopurines has been guided predominantly by clinical experience and the precise...

Journal: :Best practice & research. Clinical gastroenterology 2003
Edouard Louis Jacques Belaiche

Thioguanine derivatives, azathioprine and 6-mercaptopurine, represent major drugs in the treatment of chronic active inflammatory bowel disease. They are effective in two-thirds of the patients and safe over the long term in patients who can tolerate them (80-90%). Recent progress in understanding the metabolism of these drugs and its implication in clinical practice have brought up new tools a...

Journal: :Environmental Health Perspectives 1990
R Lorenz T Göllner K Hempel

Adult mice were Co-60 gamma irradiated, and 7 months later splenocytes were isolated, cultured in microwells, and the frequency of hprt-deficient mutants was determined by measuring the cloning efficiency in media with 6-thioguanine. The mutant frequency at 2, 4, and 6 Gy was 1.6 x 10(-5), 4.4 x 10(-5), and 12.7 x 10(-5), respectively. The frequency of spontaneous mutants was 2.5 x 10(-6). The ...

Journal: :Clinical pharmacology and therapeutics 2011
M V Relling E E Gardner W J Sandborn K Schmiegelow C-H Pui S W Yee C M Stein M Carrillo W E Evans T E Klein

Thiopurine methyltransferase (TPMT) activity exhibits monogenic co-dominant inheritance, with ethnic differences in the frequency of occurrence of variant alleles. With conventional thiopurine doses, homozygous TPMT-deficient patients (~1 in 178 to 1 in 3,736 individuals with two nonfunctional TPMT alleles) experience severe myelosuppression, 30-60% of individuals who are heterozygotes (~3-14% ...

Journal: :Cancer research 1983
B E Miller L D Roi L M Howard F R Miller

We have examined contact-mediated intercellular communication by measuring the transfer of thioguanine sensitivity to a hypoxanthine phosphoribosyltransferase (EC 2.4.2.8)-negative clone (66cl-4) selected from one subline isolated previously from a spontaneously arising mammary tumor of a BALB/cfC3H mouse. We tested other sublines from the same tumor and unrelated cell types for their ability t...

2003
DONALD L. HILL ROBERT F. PITTILLO

Of 142 purines, purine nucleosides, and analogues tested for inhibition of growth of Escherichia coli B Hill, 45 were active. Of these, 27 were evaluated for inhibition of other E. coli lines, including those resistant to 6-thioguanine, 2-fluoroadenosine, 2,6-diaminopurine, or 6-mercaptopurine. Most toxic to the parent lines were 2-fluoroadenosine, 2-fluoroadenine, 2-fluoro-5'-deoxyadenosine, a...

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