We have investigated the coordination modes of NNS Schiff base, thioether ligands to manganese(I) carbonyls. The ligands contain ortho substituted pyridines (H, CH3, OCH3, fluorophenyl) and varying substituents (H, CH3) at the Schiff base linkage. In general, reaction of [Mn(CO)5Br] with a tridentate NNS ligand in CH2Cl2 affords species in which the thioether-S may be bound or unbound to the ma...

Carboxylesterases are essential enzymes in the hydrolysis and detoxification of numerous pharmaceuticals and pesticides. They are vital in mediating organophosphate toxicity and in activating many prodrugs such as the chemotherapeutic agent CPT-11. It is therefore important to study the catalytic mechanism responsible for carboxylesterase-induced hydrolysis, which can be accomplished through th...

Tetradentate metalloenediynes with strong imine and weaker thioether coordination serve as a geometrically non-rigid switch to drive thermal Bergman cyclization.

The peroxidation of polyunsaturated fatty acids leads to numerous products, including 4-hydroxynonenal (HNE). That 4-hydroxy-2-alkenal compounds react with sulfhydryl groups of proteins to form thioether adducts possessing a carbonyl function has been established [Schauenstein, E. & Esterbauer, H. (1979) Ciba Found. Symp. 67, 225-244]. Taking advantage of the fact that Raney nickel catalyzes cl...

Galactose oxidase (EC ) is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehydes. The protein contains an unusual covalent thioether bond between a tyrosine, which acts as a radical center during the two-electron reaction, and a cysteine. The enzyme is produced in a precursor form lacking the thioethe...

The twist–bend nematic (NTB) phase is a liquid crystal (LC) with heliconical structure that typically forms below the temperature of conventional (N) phase. By contrast, direct transition between NTB and isotropic (Iso) phases without intermediation N rarely occurs. Herein, we demonstrate effects linkage type (i.e., methylene, ether, thioether) on typical Iso–N–NTB rare Iso–NTB phase-transition...

Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing thioether cross-links. We describe the preparation of seven different lantipeptides in Escherichia coli and demonstrate that this methodology can be used to incorporate nonproteinogenic amino acids.

The final urinary excretion product of selenium detoxification is trimethylselenonium ion. An assay has been developed for the enzyme, S-adenosylmethionine:thioether S-methyltransferase, responsible for this final methylation reaction. This assay employed high pressure liquid chromatography separation and quantitation of the trimethylselenonium ion produced by thioether methyltransferase acting...