A highly enantioselective dearomative Rautenstrauch rearrangement catalyzed by cationic (S)-DTBM-Segphosgold(I) is reported. This reaction provides a straightforward method to prepare enantioenriched cyclopenta[b]indoles. These studies show vast difference in enantioselectivity in the reactions of propargyl acetates and propargyl acetals in the chiral ligand-controlled Rautenstrauch reaction.

A novel palladium-catalyzed oxidative C-H functionalization protocol for the synthesis of (2-oxoindolin-3-ylidene)methyl acetates has been developed. In the presence of Pd(OAc)2 and PhI(OAc)2, a variety of N-arylpropiolamides underwent the C-H functionalization reaction with acids to afford the corresponding (E)-(2-oxoindolin-3-ylidene)methyl acetates selectively in moderate to excellent yields.

The biosynthesis of thiamine appears to be accomplished with the initial formation of the pyrimidine and thiazole moieties by independent biosynthetic pathways, followed by a final step in which 2-methyl-4-amino-5-hydroxymethylpyrimidine and 4methyl-5-(/3-hydroxyethyl) thiazole are joined together to give thiamine. This conclusion was indicated originally from the observations that certain thia...

The extract of the sea hare, Aplysia kurodai, showed cytotoxicity against HeLa cells and antibacterial activity against Staphylococcus aureus. Bioassay-guided purification afforded four active compounds, which were identified to be laurinterol, laurinterol acetate, debromolaurinterol, and debromolaurinterol acetate by spectroscopic analysis. Although the acetates were derived from laurinterol a...

A highly efficient method for the synthesis of versatile cyclopentenones from readily available enynyl acetates via tandem Au(I)-catalyzed 3,3-rearrangement and the Nazarov reaction is developed. Significant substrate flexibility and excellent control of the double bond position in the cyclopentenone ring render this an attractive method for cyclopentenone synthesis.

The cobalt-catalyzed carboxylation of propargyl acetates with CO2 (1 atm) is described. The reaction proceeds at room temperature in the presence of Mn powder as a reducing reagent. Various propargyl acetates are converted to the corresponding carboxylic acids in good to high yields.

The combination of thiazole orange (TO) and thiazole red (TR) as an internal pair of fluorescent DNA base surrogates ("DNA traffic lights") allows us to follow at least two consecutive DNA strand displacements in real time through a distinct fluorescence colour change from green to red and vice versa.

The study of the effectiveness of several potential copper corrosion inhibitors in acidic media was studied. The investigated thiazole derivative functional groups contain heterocyclic atoms such as nitrogen, sulfur, and oxygen. Thiazole derivatives, 5-benzylidene-2,4-dioxotetrahydro-1,3-thiazole (BDT) 5-(4′-isopropylbenzylidene)-2,4-dioxotetrahydro-1,3-thiazole (IPBDT), 5-(3′-thenylidene)-2,4-...