The recent interest for new applications of methylene blue as a promising drug several important ailments prompted us to fill unknown aspects related this compound. Since there is no mechanism on the Caro synthesis blue, we provide electron flow, step by step, from starting N,N-dimethylphenylenediamine dibenzothiazine derivative. It free radical generation system due oxidizing properties ferric...

A two-step sequence for the synthesis of various 3,4-dihydro-2H-1,3-thiazines is presented. In the first step, 2H-1,3-thiazines were prepared by a new multicomponent reaction (MCR). Starting from β-chlorovinyl aldehydes, this MCR offers an efficient and facile access to 2,2-dialkyl- and 2-alkyl-2-aralkyl-5,6-diaryl-2H-1,3-thiazines. The potential of these products in subsequent reactions was ve...

High performance liquid chromatography tandem mass spectrometry (HPLC MS) has been widely used for β-lactam antibiotics determination. However, its application to identify impurities of these frequently used drugs is not sufficient at present. In this job, characteristic profiles of the collision induced dissociation (CID) spectra of both β-lactams and ring-opened β-lactams were extracted from ...

BACKGROUND We have previously reported a possible anti-inflammatory activity of azulene-, tropolone- and azulenequinone-related compounds. To further pursue the newly discovered biological activity of these compounds, five compounds that inhibited nitric oxide production by activated macrophages were investigated for their possible hormetic and anti-radiation effects. MATERIALS AND METHODS Vi...

Meloxicam (MEL) (4-hydroxy-2-methyl-N-(5-methyl-2-thiazoly)-2H1,2-benzo-thiazine-3-carboxamide-1,1dioxide) (C14H13N3O4S2) (Figure 1) is a non-steroidal anti-inflammatory drug (NSAID) 1,2. MEL is a novel NSAIDs with a favorable COX-2 (cyclooxgenase-2): COX-1 (cyclooxgenase-1) selectivity has also been shown to have potent anti-inflammatory effects 3,4. Because of very low solubility of MEL in ac...