Subramanya SB, Subramanian VS, Said HM. Chronic alcohol consumption and intestinal thiamin absorption: effects on physiological and molecular parameters of the uptake process. Am J Physiol Gastrointest Liver Physiol 299: G23–G31, 2010. First published May 6, 2010; doi:10.1152/ajpgi.00132.2010.—Thiamin is essential for normal cellular functions, and its deficiency leads to a variety of clinical ...

Although no systematic studies on therapeutic value of thiamin administration in neurodegenerative diseases are available to draw statistically significant conclusion, beneficial effects of thiamin in the diseases have been observed in independent case reports. The data are usually interpreted as improvement of central metabolism due to the coenzyme role of thiamin diphosphate (ThDP) in the tra...

Thiamin (vitamin B(1)) is essential for normal cellular functions. The kidneys play a critical role in regulating body thiamin homeostasis, by salvaging the vitamin via reabsorption from the glomerular filtrate, but little is known about the mechanism(s) and regulation of thiamin transport in the human renal epithelia at cellular and molecular levels. Using the human-derived renal epithelial HE...

BACKGROUND The concentration of thiamin diphosphate (TDP) in erythrocytes is a useful index of thiamin status. We describe an HPLC method for TDP and its results in patients at risk of thiamin deficiency. METHODS We used reversed-phase HPLC with postcolumn derivatization with alkaline potassium ferricyanide and fluorescence detection. Samples were deproteinized and injected directly onto a C(...

Non-caloric nutrients (NCN) are extremely numerous and it is more than obvious that they work in a team relationship. These vitally important interactions are, for the most part, poorly understood. These brief case reports illustrate this in the therapeutic use of thiamin in a clinical setting. The initially abnormal erythrocyte transketolase activity (TKA) and/or the thiamin pyrophosphate effe...

BACKGROUND Chronic kidney disease (CKD) is associated with significant cardiovascular, neurological and metabolic complications. Thiamin and folate are essential for growth, development and normal cellular function, and their uptake is mediated by regulated transport systems. While plasma folate and thiamin levels are generally normal in patients with CKD, they commonly exhibit features resembl...

The purpose of the present experiments was to extend previous data on the strategy used by adult rats to select feed appropriately when faced with diets devoid of protein or an essential amino acid (EAA), and to compare this strategy with that used when facing vitamin (thiamin) deficiency. Rats fed on either balanced or deficient (EAA or protein) diets were offered a choice between a novel defi...

THIAMIN IS A WATER-SOLUBLE B1 vitamin that regulates critical cellular processes, such as oxidative energy metabolism, adenosine triphosphate (ATP) production, and mitochondrial function; thus, it is referred to as the energy vitamin (3, 5). Based on these known roles of thiamin, deficiency of this vitamin can lead to serious cellular impairments, including reduced cellular energy, increased ox...

Beriberi was recognised by the Chinese 3000 B.c. Tlhe etiology, however, remained obscure till 1870. In that year Eijkman, working in Java, notedl an epidemic of paralysis among fowls fed on polished rice. He found that this polyneuritis gallinarum could be cured if an extract of rice polishings were added to the diet. That polyneuritis gallinarum corresponded to human beriberi was shown by Fra...

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