We are delighted to present this special issue of The Open Biomedical Engineering (TOBEJ) focused on the current trends in mathematical modeling of high-temperature thermal therapies (ablation therapies). Clinical application and research of these therapies has seen rapid growth in the last decade, particularly for applications of cardiac arrhythmia (cardiac catheter ablation) and cancer treatm...

The aim of this study was to evaluate a flat rectangular (3×10mm(2)) MRI compatible transducer operating at 5MHz. The main task was to explore the feasibility of creating deep lesions in heart at a depth of at least 15mm. The size of thermal necrosis in heart tissue was estimated as a function of power and time using a simulation model. The system was then tested in an excised lamb heart. In th...

Percutaneous coronary laser thermal angioplasty was successfully performed before conventional balloon angioplasty in a 55 year old white man with a 90% left anterior descending artery stenotic lesion and angina at rest (Canadian Heart Association class IV). The lesion was reduced to 50% residual stenosis using a 1.7 mm laser-heated metallic capped fiber and two pulses of 8 W of argon laser ene...

The physical environment leads to a thermal sensation that is perceived and appraised by occupants. The present study focuses on the relationship between sensation and evaluation. We asked 166 people to recall a thermal event from their recent past. They were then asked how they evaluated this experience in terms of 10 different emotions (frustrated, resigned, dislike, indifferent, angry, anxio...

We investigate whether or not the Hawking-Page phase transition is possible to occur in three dimensions. Starting with the simplest class of LanczosLovelock action, thermodynamic behavior of all AdS-type black holes without charge falls into two classes: Schwarzschild-AdS black holes in even dimensions and Chern-Simons black holes in odd dimensions. The former class can provide the Hawking-Pag...

This study provides a comprehensive methodology for optimizing the design of a twophase micro-channel heat sink. The heat sink parameters are grouped into geometrical parameters, operating parameters, and thermal/fluid parameters. The objective of the proposed methodology is to optimize micro-channel dimensions in pursuit of acceptable values for the thermal/fluid parameters corresponding to a ...

BACKGROUND Temperature is a frequently used parameter to describe the predicted size of lesions computed by computational models. In many cases, however, temperature correlates poorly with lesion size. Although many studies have been conducted to characterize the relationship between time-temperature exposure of tissue heating to cell damage, to date these relationships have not been employed i...

PURPOSE To assess by means of computer simulations whether the heat sink effect inside a large vessel (portal vein) could protect the vessel wall from thermal damage close to an internally cooled electrode during radiofrequency (RF)-assisted resection. METHODS First,in vivo experiments were conducted to validate the computational model by comparing the experimental and computational thermal l...

Paget breast disease is a kind of intraductal carcinoma that through an intracanalicular diffusion invades the basal epidermal layer, reaching the areola and nipple, producing a typical erythematous desquamative eczematous-like lesion. This neoplasia can remain undetected for a long time and inadequately treated as a dermatological affection. Synchronous or metachronous lesions are very uncommo...

Although the most preferred treatment methods in cancer are still surgery and chemotherapy, microwave ablation, one of minimally invasive thermal ablation techniques, is increasingly used clinic for patients who cannot afford risks these methods. In this study, with a new NiTi ring antenna was performed on freshly slaughtered beef liver as an Ex Vivo application. Design optimization carried out...