نتایج جستجو برای: thermal inhibition
تعداد نتایج: 543669 فیلتر نتایج به سال:
Objective: To evaluate the effect of hyperglycemia on the antinociceptive activity of baclofen, a GABAB agonist, in mice. Methods: We examined the antinociceptive effect of baclofen (2.5–7.5mg/kg injected intraperitoneally) in alloxan-induced mice using the hot-plate and tail-flick tests, both thermal tests.Results: Baclofen produced a dose-dependent inhibition of hot-plate response in both no...
Despite their rigidity, microtubules in living cells bend significantly during polymerization resulting in greater curvature than can be explained by thermal forces alone. However, the source of the non-thermal forces that bend growing microtubules remains obscure. We analyzed the motion of microtubule tips in NIH-3T3 fibroblasts expressing EGFP-EB1, a fluorescent +TIP protein that specifically...
Thermal ablative therapies are important treatment options in the multidisciplinary care of patients with hepatocellular carcinoma (HCC), but lesions larger than 2-3 cm are plagued with high local recurrence rates and overall survival of these patients remains poor. Currently no adjuvant therapies exist to prevent local HCC recurrence in patients undergoing thermal ablation. The molecular mecha...
background increasing evidence indicates that opiate users and methadone maintenance patients (mmps) are impaired in executive control tasks and response inhibition behavior compared to healthy individuals; however, the cognitive functional difference between opiate addicts and mmps has not been clarified. objectives this study employed go/no-go tasks to evaluate the response inhibition behavio...
onion (allium cepa) contains high levels of flavonoids. although there are many studies indicating the inhibitory effects of flavonoids on xanthine oxidase, there is no report on the effect of onion on this enzyme. therefore, in the present study, the inhibitory effects of onion on xanthine oxidase are investigated. fresh filtered juice of onion was prepared and its inhibitory effect on guinea ...
glutathione s-transferases (gsts) are widespread in fasciola. hepatica parasite and sheep liver tissue. study of gsts inhibition assays in f. hepatica and sheep liver tissue are a priority of chemotherapeutic targets in parasitic liver diseases including human fascioliasis in iran. in this research, the whole extract of f. hepatica and sheep liver tissues were purified and eluted for sodium dod...
Heat shock produces cellular tolerance to a variety of adverse conditions; however, the protective effect of heat shock on renal cell ischemic injury remains unclear. Protein kinase C (PKC) has been implicated in the signaling mechanisms of acute preconditioning, yet it remains unknown whether PKC mediates heat shock-induced delayed preconditioning in renal cells. To study this, renal tubular c...
Background: Infection is the major cause of death in thermal injury patients. Severe suppression of the immune system is the major cause of infection following burn injury. The aim of this study was to modulate the cell-mediated immune response by the use of cimetidine and pyrimethamine in an animal burn model. Materials and Methods: Male Balb/c mice were anesthetized, and given a 10% total ...
Partial Purification and Characterisation of Polyphenol Oxidase from Tomatoes (Solanum Lycopersicum)
Polyphenol oxidase (PPO) from tomatoes was extracted and partially purified through (NH4)2SO4 precipitation, dialysis and ion exchange chromatography. The activity of polyphenol oxidase was investigated in solanum lycopersicum. Spectrophotometric method was used to assay the enzyme activity and the kinetic constants - maximum enzyme velocity (Vmax) and Michealis - Menten constant (Km). Of the ...
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