In the year 500 before Christ, the Greek philosopher Heraclitus said, “if one does not expect the unexpected, one will not find it out, since the mind is not open to it, and one will not search for it.” This is, in short, the problem I have with predicting what the future therapeutic options for Pompe disease might be. Leaving out the unthinkable, there are still plenty of options left, but how...
