Indoleamine 2,3-dioxygenase (IDO1) and tryptophane (TDO) are two heme-containing enzymes which catalyze the conversion of tryptophan to N-formylkynurenine. Both well establish therapeutic targets as important factors in tumor immune evasion mechanism. A number analogues marine pyrroloquinoline alkaloids tsitsikammamines or wakayin have been synthesized, them were synthesized using an original m...
