In geographically isolated populations where intensive medical care or serum therapy is not easily accessible snake envenomation is a major cause for concern. The aim of the present study was to test Camellia sinensis extracts, theaflavin and epigallocatechin (two of the main C. sinensis components) against the irreversible neuromuscular blockade induced by Crotalus durissus terrificus venom in...

The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for overcoming the epidemics. Traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. The H1N...

Li D, Yang C, Chen Y, Tian J, Liu L, Dai Q, Wan X, Xie Z. Identification of a PKCε-dependent regulation of myocardial contraction by epicatechin-3-gallate. Am J Physiol Heart Circ Physiol 294: H345–H353, 2008. First published October 19, 2007; doi:10.1152/ajpheart.00785.2007.—In this study, the effects of tea catechins and tea theaflavins on myocardial contraction were examined in isolated rat ...

Ras proteins play crucial roles in cell growth regulation, signal transduction and proliferation. Abnormal Ras proteins caused by genetic mutations are more common in human cancers. Activation of Ras occurs by enzymatic attachment of Farnesyl moiety by Farnesyl transferase. It has been proven that Ftase is a potential anticancer protein target. In this study we perform a virtual screening using...

The purpose of the review is to briefly list widely used 43 drugs that can be as readily available non-toxic radioprotectors and radiomitigators in GDR relevant situations. Caffeine, acetylcysteine, ceruloplasmin, ibuprofen, acetylsalicylic acid, carnosine, cyclosporine, metformin, cholecalciferol, amifostine, artemisinin, theaflavin, succinic chlorophyllin, diltiazem, ferulic glutathione, glyc...

Catechins and theaflavins, polyphenolic compounds derived from tea (Camellia sinensis, fam. Theaceae), have been reported to have a wide range of biological activities including prevention of tooth decay and oral cancer. The present study was undertaken to determine the usefulness of green tea leaves and black tea extract for the delivery of catechins and theaflavins to the oral cavity. After h...

Given the recent epidemiological evidence showing an inverse correlation between black tea intake and the risk of Parkinson’s disease, it is an intriguing possibility that theaflavins, major natural polyphenols contained in black tea, may have an anti-neurodegenerative action. In this communication, we show that theaflavins act stimulatingly on autophagy in neuronal cells. Treatment of murine N...