The Toll family of transmembrane proteins participates in signaling infection during the innate immune response. We analyzed the nine Drosophila Toll proteins and found that wild-type Toll-9 behaves similar to gain-of-function Toll-1. Toll-9 activates strongly the expression of drosomycin, and utilizes similar signaling components to Toll-1 in activating the antifungal gene. The predicted prote...

We model multiperiod securities markets with differential information. A price system that admits no free lunches is related to martingales when agents have rational expectations. We introduce a concept called resolution time and show that a better informed agent and a worse informed agent must agree on the resolution times of commonly marketed events if they have rational expectations and if t...

objective(s): high mobility group box1 (hmgb1) is a nonhistone, dna-binding protein that serves a crucial role in regulating gene transcription and is involved in a variety of proinflammatory, extracellular activities. the aim of this study was to explore whether hmgb1 stimulation can up-regulate the expression of toll-like receptor 2 (tlr2) and toll-like receptor 4 (tlr4) on macrophages from p...

This paper proposes a concept of how to collect toll on highways. Unlike any existing method, the proposed approach requires no structure to be built on highways for the toll collection purpose and drivers are not required to stop or even slow down to pay toll. Toll must be prepaid in advance and a driver must keep a toll ticket as proof of payment. We apply public key cryptographic operations ...

external exposed radiation may play an important role in pathogens of irritable bowel syndrome (ibs), although is thought to arise due to a combination of genetic and environmental factors. the result is dysregulated immune responses due to alteration in the gut microbiota population and the subsequent development of gut inflammation. it has recently been shown that the effect of ionizing radia...

the toll like (family of receptors tlr) are expressed primarily by immune cells and are known to be part of innate immune system. in the past decade involvement of tlrs in several physiologic and pathologic pathways has been proved. pain transmission via glial activation is one of such interesting fields. both pathological pain states and treatment have also been shown to be related to tlr-rela...

One of the air pollutant indices includes particulate matter with aerodynamic diameter less than or equal to 10 μg/m3 (PM10). Particulate matter has extensive effects on the respiratory and cardiovascular systems. Dissemination of such particles for a longer period can lead to increased mortality and hospitalization. In this study, the data of PM10 pollutant wer...