MOTIVATION Structural genomics eventually aims at determining structures for all proteins. However, in the beginning experimentalists are likely to focus on globular proteins to achieve a rapid basic coverage of protein sequence space. How many proteins will structural genomics have to target? How many proteins will be excluded since we already have structural information for these or since the...

Holographic Reduced Representations (HRRs) are a method for encoding nested relational structures in fixed width vector representations. HRRs encode relational structures as vector representations in such a way that the superficial similarity of the vectors reflects both superficial and structural similarity of the relational structures. HRRs support a number of operations that could be very us...

The current study uses structural equation modeling to examine adoptive parent communication as it relates to adoptee adjustment directly and indirectly through adoptive identity. Using retrospective accounts of 179 adult adoptees, findings indicate that both adoption(adoption communication openness) and non-adoption-related (parental confirmation and affectionate communication) parental commun...

A number of fundamental questions in structural biology concern the diversity of protein architectures (or folds). Here, we address two of them, the size of the universe of folds, and the distribution of sequence families among them, using an analysis based on a new and rigorous statistical sampling method. In particular we show that the number of known non-transmembrane protein folds is approx...

We attempt to formulate several mathematical problems suggested by structural patterns present in biomolecular assemblies. Our description of these patterns, by necessity brief and over-concentrated in some places, is self-contained, albeit on a superficial level. An attentive reader is likely to stumble upon a cryptic line here and there; however, things will become more transparent at a secon...