The incidence of mongolism increases so remarkably with advancing maternal age that it hardly seemed necessary to earlier workers to know the maternal age structure of the population from which their cases were drawn (Shuttleworth, 1909; Brousseau, 1928; Engler, 1949), or to ensure that the control group was representative (Jenkins, 1933; Rosanoff and Handy, 1934; Lahdensuu, 1937; Bleyer, 1938;...

in research on the history of medicine, less attention is paid to the subject of historical geography . considering the importance of this subject in the history of science, this paper discusses one of the most important science centers in the world. this outstanding medical research center was located in gorganch city, chorasmia area, in the eastern part of the islamic. chorasmia medical schoo...

Though the basic cause or causes responsible for the chromosomal aberration in mongolism are still obscure, it is generally agreed that the standard trisomic karyotype in this condition originates in the ovary. Measures of ovarian function could therefore be helpful in elucidating some of the factors involved. In this connexion, an opportunity arose to compare the stated age of onset of menstru...