The anti-diabetic metformin has been demonstrated to be effective in suppression of tumor progression via multiple mechanisms, in which angiogenic inhibition is involved. Hypoxia is a common feather of malignant tumor and promotes angiogenesis via induction of pro-angiogenic factors. However, the effect of metformin on tumor hypoxia and the association with angiogenic inhibition are still uncle...

Congestion is one of the main issues in data envelopment analyses which have particular importance. Recently researches about congestion, whether in economic articles or in Operations Research articles in had grown increasingly. Congestion is a wasteful stage of the production process where outputs are reduced due to excessive amount of inputs. In economics, congestion is very important because...

abnormalities of blinking in childhood are not uncommon. to determine the characteristics and causes of excessive blinking, this prospective, non–comparative consecutive case series study was carried out. in outpatient clinics of ophthalmology and neurology of our hospital, 60 children aging 2-16 years old with excessive blinking were examined. detailed ophthalmologic and neurologic evaluation ...

this study attempts to identify and evaluate the factors affecting excessive buying that is of high interests theoretically and practically. at first some scales will be developed based on past researches and existing classifications to represent the logical and conceptual varieties in buying excessively. then, psychometric properties of the scales are tested by analyzing the factors confirming...

obejective(s): in this research, magnetite nanoparticles with an average size of 23-36 nm were successfully synthesized via surfactant-free electrochemical method using iron as the anode and water as the electrolyte in a closed aqueous system in the presence of naoh at room temperature. methods: the effect of the current density on product formation and particle size was investigated. particle ...

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Two Japanese persons with consanguinous parents had a motor and sensory neuropathy of the hypertrophic type with excessive myelin outfolding in the myelinated fibers. A morphometric analysis of the biopsied sural nerve was made. Excessive myelin outfolding, segmental demyelination, and remyelination and decrease in the density of both large and small myelinated fibers were evident. Using linear...