نتایج جستجو برای: the c3435t mdr1 polymorphism
تعداد نتایج: 16069836 فیلتر نتایج به سال:
BACKGROUND/AIM Multidrug resistance 1 (MDR1) gene encodes for P-glycoprotein (P-gp), a transmembrane efflux pump transferring both exogenous and endogenous substrate from the cells. In the human gastrointestinal tract, P-gp is found in high concentrations on the epithelial cells of the colon and small intestine. It is hypothesized that the expression level of MDR1 gene is related to susceptibil...
Functional single nucleotide polymorphism (SNP) C3435T in exon 26 of the MDR1 ( ABCB1 ) gene encoding the xenobiotic transporter P-glycoprotein (P-gp, MDR1, ABCB1) may influence susceptibility to several diseases as well as clinical outcome of treatment with P-gp substrates. Exposure to environmental chemicals is thought to be involved in the pathogenesis of B-cell chronic lymphocytic leukemia ...
Altered MDR1 expression and/or function contribute to the pathogenesis of inflammatory bowel disease (IBD). DNA methylation was shown as an important mechanism in gene silencing. We investigated DNA methylation of the MDR1 gene in ulcerative colitis (UC) and its relation to MDR1 C3435T genotypes. Eighty-three UC patients were enrolled. Methylation of MDR1 promoter was determined by methylation ...
BACKGROUND Inflammatory bowel diseases (IBD) are chronic diseases of unknown etiology and pathogenesis in which genetic factors contribute to development of disease. MDR1/ABCB1 is an interesting candidate gene for IBD. The role of two single nucleotide polymorphisms, C3435T and G2677T remains unclear due to contradictory results of current studies. Thus, the aims of this research were to invest...
AIM to reveal the role of polymorphism C3435T of MDR-1 gene in the response to preoperative chemotherapy in locally advance breast cancer. METHODS the analytical observational research in nineteen patients diagnosed between January and December 2005 with locally advanced breast cancer treated by preoperative Anthracycline chemotherapy to evaluate its predictive outcome was performed. On all s...
سابقه و هدف : گلیکوپروتئین p محصول ژن mdr1 (ژن مقاومت چند دارویی)، پمپ داخل غشایی است که در انتقال سموم و داروها از داخل سلول به خارج آن نقش دارد. در دستگاه گوارش انسان، گلیکوپروتئین p با غلظت های بالایی در سلولهای اپیتلیال روده یافت می شود. پلیمورفیسم های ژن mdr1 از جمله c3435t با ساخت کمتر گلیکوپروتئین p همراهی دارند و به نظر می رسد با بیماری های التهابی روده بخصوص کولیت اولسرو در ارتباط ...
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