a complete diet (total mixed ration) with sorghum stover (40%) as sole roughage source was prepared and offered to animals under two forms: as mash or as expanded-extruded pellets (eep). these two complete diets were compared with a conventional diet (ad libitum chopped sorghum stover fed separately with concentrate mixture to meet 80% of protein requirements). these three diets were randomly a...

OBJECTIVES The purpose of this study was to determine the paired consequences of food restriction and paradoxical sleep deprivation on lipid profile and spontaneous glucose levels in male rats. METHOD Food restriction began at weaning, with 6 g of food being provided per day, which was subsequently increased by 1 g per week until reaching 15 g per day by the eighth week. At adulthood, both ra...

1. A method of obtaining dialysed samples from the caecum of the conscious rabbit is described. 2. Values for total volatile fatty acid content and for molar proportions of individual volatile fatty acids in dialysate samples were in good agreement with those obtained from caecal material. 3. The volatile fatty acid level in the caecum throughout the day was determined using two groups of anima...

Hypothalamus is the highest center and the main crossroad of numerous homeostatic regulatory pathways including reproduction and energy metabolism. Previous reports indicate that some of these functions may be driven by the synchronized but distinct functioning of the left and right hypothalamic sides. However, the nature of interplay between the hemispheres with regard to distinct hypothalamic...

The effect of severe ascorbic acid deficiency on bone remodeling and collagen synthesis was evaluated in a 21 day experiment, using the scorbutic guinea pig model. Animals (n = 6-7/group) were assigned to one of three groups: scorbutic, pair-fed ascorbic acid-replete, or ad libitum ascorbic acid-replete groups. After 2 weeks, scorbutic animals started voluntarily decreasing food intake and losi...

The mechanism(s) by which dietary restriction (DR) suppresses ageing and onset of age-related pathologies are discussed in relation to frequency of glycolysis, and the reactivity of glycolytic intermediates. Most glycolytic intermediates are potentially toxic and readily modify (i.e. glycate) proteins and other macromolecules non-enzymically. Attention is drawn to the reactivity of methyglyoxal...

The studies employed the cholesterol-fed rabbit model of Alzheimer's disease (AD) to investigate the relationship between AD-like neurofibrillary tangle (NFT) neuropathology and tau protein levels as the main component of NFT. We measured brain and plasma tau levels and semiquantified NFT-like neuropathology in cholesterol-fed rabbits administered drinking water of varying quality (distilled, t...

Cytochrome oxidase activity and mitochondrial GDP binding were decreased in brown adipose tissue of mice treated chronically with corticosterone. These changes occurred both in corticosterone-treated mice fed ad libitum and in treated mice pair-fed to control animals. Although the dietary stimulation of brown-adipose-tissue thermogenesis was suppressed by corticosterone, the acute response to c...

Effect of Fasting on the Toxicity and Serum Concentration of Aminopyrine in Rats. CORNISH, HERBERT H., MORRISON, A. B., and NELSON, JOHN M. (1970). Toxicol. Appl. Pharmacol. 17,217-222. The acute oral toxicity of aminopyrine is considerably greater in the fasted rat than in the fed rat. Acute toxicity by the ip route was comparable in these two groups of animals. Serum aminopyrine concentration...

Four donkeys and four ponies were fed molassed dehydrated alfalfa or oat straw, either ad libitum or restricted to about 70% ad libitum intake in a Latin-square design for four periods of 21 d. Measurements of apparent digestibility and gastrointestinal transit time were made on the last 7 d of each period. When the forages were provided ad libitum, all animals ate significantly more of the alf...