Background/Aim. The studies of hydroxyapatite (HAp) and growth factors as the materials used for direct pulp capping have produced conflicting results both issue inflammatory response calcified bridge formation. Hap/poly (lactide-co-glycolide) (HAp/PLGA) is a bioresorbable polymer with demonstrated good characteristics carrier bone morphogenetic protein necessary in tissue regeneration. role de...

Background: Laparoscopy induces changes and detachment of mesothelial structure. Studies on the prevention cell are rarely found. The Dayak tribe uses onion (Eleutherine americana L. Merr) as a wound-healing agent due to its anti-inflammatory antioxidant activities. This study aimed prove activities onions in preventing damage after laparoscopy.
 Materials methods: Thirty male Sprague-Dawl...

Abstract Glomerular podocytes are integral members of the glomerular filtration barrier in kidney and crucial for permselectivity. These highly differentiated cells vulnerable to an array noxious stimuli that prevail several diseases. Elevated circulating growth hormone (GH) levels associated with podocyte injury proteinuria diabetes. However, precise mechanism(s) by which excess GH elicits pod...

introduction: astrocytes, the most abundant glia in the central nervous system, modulate neuronal survival and function. astrocytic functions are mediated by synthesis and secretion of wide ranges of polypeptides through mechanism (s) poorly understood. among these, tgfβs are synthesized and released by the astrocytes. in this study, the involvement of wnt signaling pathway on the synthesis of ...

<b><i>Introduction:</i></b> The homeodomain transcription factor sine oculis homeobox homolog 1 (Six1) plays a crucial role in embryogenesis and is not expressed normal adult tissue but many pathological processes, including airway remodelling asthma. current study aimed to reveal the effects of Six1 regulating its possible mechanism. <b><i>Methods:</i>...

Fine particulate matter (PM2.5) is an important component of air pollution and can induce lung inflammation oxidative stress. We hypothesized that PM2.5 could play a role in the induction pulmonary fibrosis. examined whether multiple intranasal instillation fibrosis mouse, also investigated underlying pro-fibrotic signaling pathways. C57/BL6 mice were intranasally instilled with 50 ?l suspensio...

Cardiac fibrosis is a pathological process associated with the development of heart failure. TGF-? and WNT signaling have been implicated in pathogenesis cardiac fibrosis, however, little known about molecular cross-talk between these two pathways. The aim this study was to examine effect exogenous canonical WNT3a non-canonical WNT5a TGF-?-activated human fibroblasts. We found that induced ?-ca...

Transforming growth factor (TGF)-beta(1) is one of the most pleiotropic and multifunctional peptides known. While the cardioprotective effect of TGF-beta(1) during ischemia is well known, the specific role of TGF-beta(1) in altering the cardiac remodeling process remains unclear. This study was designed to examine the regulation of hypoxia-reoxygenation-mediated collagen type I expression and a...