Role of Tenoxicam in The Prevention of Postlaminectomy Peridural Fibrosis in Rats Mete KARATAY, Haydar CELİK, Ender KOKTEKİR, Eylem KARATAY, Idris SERTBAS, Ali YILMAZ, Muzaffer CAYDERE, Hakan KARABAGLİ Ministry of Health Ankara Training and Research Hospital, Neurosurgery, Ankara, Türkiye Gazi University, Faculty of Medicine, Gastroenterology, Ankara, Türkiye Selcuk University, Faculty of Medic...

The phisico-chemical properties of bio-and drug molecules greatly influence their interactions in the body and strongly effect the mechanism of drug action. Among these properties, macroscopic and site-specific protonation constants are of crucial importance. Latter one is the tool to calculate the relative concentration of the various microspecies in the compartments of the body at different p...

BACKGROUND The efficacy and safety of antithrombotic treatment in patients with superficial vein thrombosis remain to be established in adequately designed trials. METHODS In a double-blind trial, 427 patients older than 18 years, with documented acute symptomatic superficial vein thrombosis of the legs, were randomly assigned to receive subcutaneous enoxaparin sodium, 40 mg; subcutaneous eno...

BACKGROUND Matrix metalloproteinases (MMPs) and cytokines play a role of extracellular matrix degradation and remodelling, and are significantly involved in the course of periodontal disease. OBJECTIVES The purpose of this study was to evaluate the adjunctive effect of administering an oxicam non-steroidal anti-inflammatory drug (NSAID), tenoxicam, during non-surgical (phase 1) periodontal tr...

The first-line treatment of osteoarthritis is based on anti-inflammatory drugs, the most currently used being nonsteroidal selective cyclooxygenase 2 (COX-2) inhibitors and corticoids. Most them present cytotoxicity low bioavailability in physiological conditions, making necessary administration high drug concentrations causing several side effects. goal this work was to encapsulate three hydro...

BACKGROUND In some patterns of cutaneous adverse drug reactions, and depending on the culprit drug, patch testing has been helpful in confirming its cause. Its value in Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) has not been established in a large cohort of patients. OBJECTIVE The aim of the present study is to evaluate the safety and usefulness of patch testing in DRESS. PAT...