Prevalensi stroke terus meningkat setiap tahun. Penanganan kasus harus dilakukan sesegera mungkin untuk memaksimalkan pemulihan serta mencegah berulang. Pada iskemik akut, pengobatan fibrinolitik tPA terbukti efektif. Beberapa kriteria pemberian dipenuhi. Pasien yang mendapat observasi tekanan darah ketat dan memastikan tidak terjadi efek samping perdarahan. Hingga saat ini, hanya alteplase dis...

Objective This real-world, observational, prescription event monitoring study was conducted to evaluate safety and efficacy of indigenous tenecteplase (TNK-tPA) in Indian patients presenting with ST elevation myocardial infarction (STEMI). Methods This is a multi-centric, observational, prescription event monitoring study. Data was collected for 7,668 patients from 1,307 investigator sites ac...

Introduction: Alteplase is widely used as an intravenous thrombolytic drug in acute ischemic stroke (AIS). Recently however, tenecteplase, a modified form of tissue plasminogen activator, has been shown to increase early recanalization rate and proven be non-inferior with similar safety profile compared alteplase. This study aims evaluate the cost-effectiveness 0.25 mg/kg tenecteplase versus 0....

INTRODUCTION Drotrecogin alfa (activated) (DrotAA), an activated protein C, promotes fibrinolysis in patients with severe sepsis. There are no reported cases or studies that address the diagnosis and treatment of myocardial infarction in septic patients treated with DrotAA. CASE PRESENTATION A 59-year-old Caucasian man with septic shock secondary to community-acquired pneumonia treated with D...

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The use of fibrinolytic agents in the early treatment of ST-segment elevation myocardial infarction (STEMI) is known to significantly reduce mortality. Accelerated (“frontloaded”) alteplase is being challenged as the standard of care for pharmacological reperfusion. Alteplase, reteplase, and streptokinase have several limitations. The search for newer agents has focused on developing a fibrinol...

Intravascular thrombosis plays a fundamental role in the pathophysiology of cardiac arrest. Autopsy results from cases of unsuccessful resuscitation and coronary angiography in survivors of out-of-hospital cardiac arrest suggest that 50-70% of deaths can be attributed to thrombosis in the form of myocardial infarction or pulmonary embolism [2,3]. Ischemia and reperfusion during resuscitation fr...

Background: Sex differences in treatment response to intravenous thrombolysis (IVT) are poorly characterized. We compared sex-disaggregated outcomes patients receiving IVT for acute ischemic stroke the Alteplase Tenecteplase (AcT) trial, a Canadian multicentre, randomised trial. Methods: In this post-hoc analysis, primary outcome was excellent functional (modified Rankin Score [mRS] 0-1) at 90 ...

background: phic31 integrase is a dna site-specific recombinase integrates dna into the chromosomes between the two sites of attb and attp. several pseudo attps have been identified in mammalian genomes with critical features for long-term expression of transgene. in this manuscript, we report a novel intrinsic pseudo attp site named chol1 in the chinese hamster genome implementing an inverse p...