Telomeric repeat-containing RNA (TERRA) controls the structure and length of telomeres through interactions with numerous telomere-binding proteins. However, little is known about the mechanism by which TERRA regulates the accessibility of the proteins to telomeres, mainly because of the lack of spatiotemporal information of TERRA and its-interacting proteins. We developed a fluorescent probe t...

Background: The ultrasonography probes are cleaned by absorbent soft, dry cloth. This question arose whether linear and convex ultrasound probes coupling with gel could perform as a means for nosocomial infections transmission, and which method is economical and more efficient for cleaning the probes. This study was conducted to answer these questions. Methods: One hundred – ninety two patients...

This study analyzed the karyotype of Cyrtodactylus inthanon Kunya et al., 2015 from Doi Inthanon, Chiang Mai Province, northern Thailand. The metaphase and meiotic chromosome preparations were obtained by squash technique bone marrow testes, respectively. chromosomes stained Giemsa staining, Ag-NOR banding molecular cytogenetics with ?uorescence in situ hybridization (FISH) using microsatellite...

EDITOR—The genetic causes of mental retardation are still largely unknown so that about 34% of cases of severe to moderate and 80% of mild mental retardation remain unresolved. 2 Consequently, genetic counselling is diYcult in these cases. Chromosomal rearrangements are still the most frequent cause of mental retardation and cytogenetic analysis at 400-550 band resolution cannot detect rearrang...

Abstract Capsicum pubescens is a cultivated hot chili pepper, consumed in Latin American cuisine as distinctive ingredient, and popularly known “locoto” or “rocoto”. This taxon also an outstanding source of resistance to biotic abiotic stresses well other valuable fruit traits for breeding the worldwidely C. annuum related species. In this study, chromosome complement cv. (2n = 24) was deeply c...

Malarial parasite P. falciparum, an apicomplexan protozoan has a 23.3 MB nuclear genome and encodes ~ 5600 transcripts. The genetic diversity of the parasite within and across geographical zones is a challenge to gene expression studies which are essential for understanding of disease process, outcome and developing markers for diagnostics and prognostics. Here, we describe the strategy involve...

The development of biophysical systems that enable an understanding of the structure and ligand-binding properties of G-quadruplex (GQ)-forming nucleic acid sequences in cells or models that mimic the cellular environment would be highly beneficial in advancing GQ-directed therapeutic strategies. Herein, the establishment of a biophysical platform to investigate the structure and recognition pr...

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited predisposition to neoplastic lesions of the parathyroids, pancreas, and the pituitary. We have previously located the predisposing genetic defect to the long arm of chromosome 11 by genetic linkage. In this study, 124 members of six MEN1 families, including 59 affected individuals, were genotyped for restriction fra...

Triticum genus encloses several tetraploid species that are used as genetic stocks for expanding the genetic variability of wheat (Triticum aestivum L.). Although the T. aestivum (2n = 6x = 42, AABBDD) and T. durum (2n = 4x = 28, AABB) karyotypes were well examined by chromosome staining, Giemsa C-banding and FISH markers, other tetraploids are still poorly characterized. Here, we established a...

Unbalanced translocations as well as interstitial deletions of the short arm of chromosome 12 [del(12p)] are found as recurring chromosomal changes in a broad spectrum of hematopoietic malignancies. These changes result in the hemizygous deletion of genetic material from 12p. We mapped a yeast artificial chromosome containing the TEL gene, a cosmid contig containing part of TEL and a P1 contig ...