Adenosine deaminase (ADA) is responsible for the deamination of immunosuppressive adenosine to inosine. In human T lymphocytes, ADA is associated with dipeptidyl peptidase IV (CD26). ADA expression and activity were evaluated in regulatory T cells (Treg) and CD4(+) T effector cells (Teff) of patients with head and neck squamous cell cancer (HNSCC). CD4(+)CD39(+) and CD4(+)CD39(neg) T cells were...

An extensive grid of synthetic midand far-ultraviolet spectra for accretion disks in cataclysmic variables has been presented by Wade and Hubeny (1998). In those models, the disk was assumed to be in steady-state, that is Teff(r) is specified completely by the mass MWD and radius RWD of the accreting white dwarf star and the mass transfer rate Ṁ which is constant throughout the disk. In these m...

The relationships between the effective surface (Teff ) and internal temperatures of neutron stars (NSs) with and without accreted envelopes are calculated for Teff > 5 × 104 K using new data on the equation of state and opacities in the outer NS layers. We examine various models of accreted layers (H, He, C, O shells produced by nuclear transformations in accreted matter). We employ new Opacit...

Teff [Eragrostis tef (Zucc.) Trotter] is a relatively new forage crop that is attracting much interest among hay growers in the United States and Utah (Creech, et al., 2012). Teff plants have fine stems, shallow roots and are not frost tolerant. This annual, warm-season grass grows best during the hottest months of the year when cool-season grasses suffer their “summer slump.” Since Teff does n...

Clinically effective antigen-based immunotherapy must silence antigen-experienced effector T cells (Teff) driving ongoing immune pathology. Using CD4(+) autoimmune Teff cells, we demonstrate that peptide immunotherapy (PIT) is strictly dependent upon sustained T cell expression of the co-inhibitory molecule PD-1. We found high levels of 5-hydroxymethylcytosine (5hmC) at the PD-1 (Pdcd1) promote...

Introduction Grass pea (Lathyrus sativus) is one of the important food legumes in countries like Bangladesh, India, and Ethiopia. It has desirable agronomic characteristics, notably the ability to resist adverse climatic conditions. Nutritionally it is tasty and protein-rich. However over consumption can cause an upper motor neuron disease known as neurolathyrism, an irreversible paraparesis of...

We describe a scheme to extract linearly supporting (LSU) features from stellar spectra to automatically estimate the atmospheric parameters Teff, log g, and [Fe/H]. “Linearly supporting” means that the atmospheric parameters can be accurately estimated from the extracted features through a linear model. The successive steps of the process are as follow: first, decompose the spectrum using a wa...

Advances in cancer immunotherapy have offered new hope for patients with metastatic disease. This unfolding success story has been exemplified by a growing arsenal of novel immunotherapeutics, including blocking antibodies targeting immune checkpoint pathways, cancer vaccines, and adoptive cell therapy (ACT). Nonetheless, clinical benefit remains highly variable and patient-specific, in part, b...

Seed storage proteins (SSP) in cereals provide essential nutrition for humans and animals. Genes encoding these proteins have undergone rapid evolution in different grass species. To better understand the degree of divergence, we analyzed this gene family in the subfamily Chloridoideae, where the genome of teff (Eragrostis tef) has been sequenced. We find gene duplications, deletions, and rapid...