Advanced glycation end products (AGEs) increase with aging and induce signaling alterations that lead to inflammation and dysfunction in several tissues. Aging reduces function and insulin signaling in lacrimal glands (LGs). To evaluate whether AGE signaling and insulin secretion in LGs are altered in aging, 24- and 2-month-old male Wistar rats were compared. Immunohistochemistry with confocal ...

PURPOSE To investigate the changes in tear secretion and tear film stability after excimer laser in situ keratomileusis (LASIK) for high myopia. METHODS One eye of 28 patients underwent unilateral LASIK for the correction of myopia with spherical equivalent refractions ranging from -6.37 to -18.25 D (mean, -11.98 +/- 3.45 D). Schirmer tear test values without anesthesia at 5 minutes and tear ...

The first aim of this study was to clarify whether cigarette smoking affects tear secretion, goblet cell density, and tear MUC5AC concentration. The second purpose was to evaluate the correlations of conjunctival goblet cell density with tear MUC5AC concentration and other ocular surface evaluation factors. This cross-sectional study included 88 office workers. All subjects were required to fil...

BACKGROUND Diabetic patients often complain of dry eye symptoms, such as burning and/or foreign body sensation. The aim of the present study was to investigate whether diabetes mellitus is correlated with tear film dysfunction and/or tear hyposecretion. METHODS In 86 consecutive insulin dependent diabetics with retinopathy and 84 non-diabetic controls (age and sex matched) we performed fluoro...

purpose: to report a case of duane's retraction syndrome with dry eye. patient and findings: an 18-year-old girl presented with chief complaint of limited abduction in her right eye. best corrected visual acuity was od: 8/10 and os: 9/10. ocular motility examination revealed severe abduction limitation (-4), mild adduction limitation (-1), and moderate upshoot and mild downshoot in the rig...

Background: The therapeutic administration of 131I for thyroid remnant ablation and for metastases comes up with some adverse effects. This study was conducted to investigate whether single high dose radioiodine therapy affects lacrimal gland functions or not. Materials and Methods: Seventy-eight eyes of 39 patients, who were diagnosed as differentiated thyroid carcinoma, were objectively teste...

To investigate the tear film in the closed eye, microliter tear samples were collected without overt reflex stimulation throughout the diurnal cycle, with closed eye samples recovered immediately upon eye opening. Samples were subjected to agarose, polyacrylamide, and two-dimensional electrophoresis, coupled with immunofixation, immunoblot, and lectin blot assays. Major protein constituents wer...

We investigated the tear secretion-stimulating effect of cyclosporin A (CyA) eyedrops in rabbits using Schirmer's method. The following findings were obtained: (1) CyA induced tear secretion in a concentration-dependent manner. CvA in 0.1% concentration showed the strongest effect in accelerating lacrimation, and this effect persisted from 3 to 8 hours after instillation. (2) CyA-induced lacrim...

Purpose: The present study aimed to review the effect of dehydration during Ramadan fasting on the health and ocular parameters leading to changes in eye function. Methods: Articles included in the study were taken from Pub Med, Ovid, Web of Science and Google Scholar up to 2014.Related articles were also obtained from scientific journals in fasting and eye. Results: Dehydration and nutrition c...