Tracheal cytotoxin (TCT), a naturally occurring fragment of Gram-negative peptidoglycan, is a potent elicitor of innate immune responses in Drosophila. It induces the heterodimerization of its recognition receptors, the peptidoglycan recognition proteins (PGRPs) LCa and LCx, which activates the immune deficiency pathway. The crystal structure at 2.1 angstrom resolution of TCT in complex with th...

BACKGROUND AND PURPOSE The aim of the present study was to test the hypothesis that perfusion single-photon emission computed tomography (SPECT), carried out in addition to transmission computed tomography (TCT), improves the predictive value of brain imaging within the therapeutically relevant time window after acute cerebral ischemia. METHODS Using TCT and [(99m)Tc]ethyl cysteinate dimer (E...

Large size photovoltaic (PV) systems face a large number of issues based on malfunction and unfavourable climatic conditions such as partial shading (PSCs). These PSCs are the major causes PV systems’ performance degradation. In this paper, symmetric matrix (SM) game puzzle is used to reconfigure electrical connections array system. Present shade dispersion methodology ‘physical reallocation mo...

A practical, mild and efficient protocol for the Pictet-Spengler reaction catalyzed by cyanuric chloride (trichloro-1,3,5-triazine, TCT) is described. The 6-endo cyclization of tryptophan/tryptamine and modified Pictet-Spengler substrates with both electron-withdrawing and electron-donating aldehydes was carried out by using a catalytic amount of TCT (10 mol %) in DMSO under a nitrogen atmosphe...

The formation of intramolecular triplex DNA can be regulated by Ag(+) and Cys (cysteine), which switch off/on the fluorescence of the oligonucleotides, 5'-TAMRA-TTC TCT TCC TCT TCC TTC TGA CGA CAG TTG ACT CTT CCT TCT CCT TCT CTT-BHQ-2-3' (Oligo 1) and 3'-GAA GGA AGA GGA AGA GAA-5' (Oligo 2). Based on this principle, sensors for Ag(+) and Cys are developed. The sensor for Ag(+) has a linear rang...

This paper presents a novel method to solve non-linear time-cost tradeoff (TCT) problem of real world engineering projects. Multiobjective genetic algorithm (MOGA) is employed to search for optimal TCT profile. Applicability of ANN based model for rapid estimation of time-cost relationship by invoking its function approximation capability is investigated. ANN models are then integrated with MOG...

We have investigated the synergistic interactions of a naturally occurring peptidoglycan fragment (muramyl peptide) and bacterial endotoxin in the induction of inflammatory processes within respiratory epithelial cells, at the levels of both signal transduction events and ultimate cellular metabolic effects. The source of the muramyl peptide is Bordetella pertussis, the causative agent of the r...

The risk of human exposure to total chlorotriazines (TCT) in drinking water was evaluated using a physiologically based pharmacokinetic (PBPK) model. Daily TCT (atrazine, deethylatrazine, deisopropylatrazine, and diaminochlorotriazine) chemographs were constructed for 17 frequently monitored community water systems (CWSs) using linear interpolation and Krieg estimates between observed TCT value...

this study presents the effects of project uncertainties on nonlinear time-cost tradeoff (tct) profile of real life engineering projects by the fusion of fuzzy logic and artificial neural network (ann) models with hybrid meta-heuristic (hmh) technique, abridged as fuzzy-ann-hmh. nonlinear time-cost relationship of project activities is dealt with ann models. ann models are then integrated with ...

Two non-medical treatment strategies for chronic idiopathic tinnitus were evaluated in a randomized control group design. A cognitive-behavioural tinnitus coping training (TCT) was developed and compared to yoga and a self-monitoring control condition. Forty-three chronic tinnitus patients, were assessed at baseline, directly after therapy, and at 3 months follow-up. For evaluation, differentia...