نتایج جستجو برای: tc 99m trodat 1

تعداد نتایج: 2773202  

Journal: :Journal of nuclear medicine technology 1999
P Fang B C Wang C Y Wu W X Wan N Y Jiang X Zhou Z P Chen

OBJECTIVE The biological properties of a new neutral myocardial imaging agent 99mTcN(NOEt)2 were evaluated. METHODS Blood clearance in rabbits, biodistribution in rats, and initial myocardial imaging in dogs were performed. RESULTS Radiochemical purity of 99mTcN(NOEt)2 was more than 90% and stable for 6 h at room temperature. Blood disappearance was analyzed with a biexponential model and T...

Journal: :Journal of psychopharmacology 2005
G J E Schmitt E M Meisenzahl T Frodl C La Fougère K Hahn H-J Möller S Dresel

Following the current hypothesis that acute schizophrenic psychotic illness is associated with a striatal 'hyperdopaminergic state', presynaptic integrity and dopamine transporter (DAT) density in first-episode, neuroleptic-naive schizophrenic patients was measured by single-photon-emission-tomography (SPECT) and compared with that in healthy control subjects. A new SPECT-ligand for assessment ...

Journal: :Schizophrenia bulletin 2013
Kao Chin Chen Yen Kuang Yang Oliver Howes I Hui Lee Sabine Landau Tzung Lieh Yeh Nan Tsing Chiu Po See Chen Ru Band Lu Anthony S David Elvira Bramon

Central dopaminergic hyperactivity has been one of the main hypotheses of the pathophysiology of schizophrenia since the 1970s. Excess dopamine (DA) neurotransmission in the striatum is hypothesized to alter the processing of information and result in psychotic symptoms in schizophrenia. Single photon emission computerized tomography (SPECT) provides in vivo indices of DA neurotransmission. Our...

2016
Yanli Li Yan Hu Jie Xiao Guobing Liu Xiao Li Yanzhao Zhao Hui Tan Hongcheng Shi Dengfeng Cheng

SP94 (SFSIIHTPILPL), a novel peptide, has shown specific binding to hepatocellular carcinoma (HCC) cells. We aimed to investigate the capability of SP94 as a targeting probe for HCC imaging and therapy following labeling with technetium-99m ((99m)Tc) and rhenium-188 ((188)Re). HYNIC-SP94 was prepared by solid phase synthesis and then labeled with (99m)Tc. Cell competitive binding, internalizati...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013
Julien Dimastromatteo Alexis Broisat Pascale Perret Mitra Ahmadi Didier Boturyn Pascal Dumy Daniel Fagret Laurent M Riou Catherine Ghezzi

UNLABELLED Vascular cell adhesion molecule 1 (VCAM-1) plays a major role in the chronic inflammatory processes involved in vulnerable atherosclerotic plaque development. We previously showed that the (99m)Tc-labeled major histocompatibility complex 1-derived peptide B2702p bound specifically to VCAM-1 and allowed the ex vivo imaging of atherosclerotic lesions in Watanabe heritable hyperlipidemi...

2013
Masoud Sadeghzadeh Ghorbanali Charkhlooiea Fariba Johari Daha

Two deoxyglucose (DG) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-D-glucose (ECB-DG) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-D-glucose (DHP-DG), were synthesized and radiolabeled successfully with [(99m)Tc(H2O)3(CO)3](+) complex. [(99m)Tc]-ECB-DG and [(99m)Tc]-DHP-DG complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mCi of Na(99m)TcO4 in 1 mL sa...

Journal: :Clinical physiology and functional imaging 2012
D S Mshelia A N Hatutale N P Mokgoro M E Nchabaleng J R Buscombe M M Sathekge

AIM The goal of the study is to correlate serum calcium levels with the results of dual-phase (99m)Tc-sestamibi parathyroid scintigraphy to find the best cut-off level of the serum calcium that correlates with a positive presurgery. METHODS In 111 patients, serum calcium and plasma parathormone (PTH) levels were compared with the results of the (99m)Tc-MIBI scintigraphy and with this data det...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008
Seigo Ishino Takahiro Mukai Yuji Kuge Noriaki Kume Mikako Ogawa Nozomi Takai Junko Kamihashi Masashi Shiomi Manabu Minami Toru Kita Hideo Saji

UNLABELLED Lectinlike oxidized low-density lipoprotein (LDL) receptor 1 (LOX-1), a cell surface receptor for oxidized LDL, has been implicated in vascular cell dysfunction related to plaque instability, which could be a potential target for an atherosclerosis imaging tracer. In this study, we designed and prepared (99m)Tc-labeled anti-LOX-1 monoclonal IgG and investigated its usefulness as an a...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2016
Zhonglin Liu Brian D Gray Christy Barber Michael Bernas Minying Cai Lars R Furenlid Andrew Rouse Charmi Patel Bhaskar Banerjee Rongguang Liang Arthur F Gmitro Marlys H Witte Koon Y Pak James M Woolfenden

Molecular probes capable of detecting colorectal cancer (CRC) are needed for early CRC diagnosis. The objective of this study was to characterize c[CTPSPFSHC]OH (TCP-1), a small peptide derived from phage display selection, for targeting human CRC xenografts using technetium-99m ((99m)Tc)-labeled TCP-1 and fluorescent cyanine-7 (Cy7)-labeled form of the peptide (Cy7-TCP-1). (99m)Tc-TCP-1 was ge...

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