The purpose of the present study was to evaluate the enhancement of tolbutamide (TBM) oral bioavailability and hypoglycaemic activity through complexation with beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD). TBM and its freeze-dried inclusion complexes were administered to rabbits (New zealand breed; n=6), in a dose of 20 mg/kg. TMB plasma levels were measured by H...

BACKGROUND Varicella-zoster virus (VZV) is one of the most common etiologies of aseptic meningitis. The severest manifestation of VZV meningitis is occasionally confused with tuberculous meningitis (TBM). Thus, we investigated the clinical manifestations of VZV meningitis as compared with those of TBM. MATERIALS AND METHODS All adult patients who were diagnosed with VZV meningitis or TBM were...

This paper deals with the conceptual design of Experimental Helium Cooling Loop (EHCL) for Indian Test Blanket Module (TBM) and its related thermal hydraulic experiments. Indian TBM team is developing Lead Lithium cooled Ceramic Breeder (INLLCB) TBM to be tested in ITER. The TBM box structure is cooled by high pressure (8 MPa) and high temperature (300-500C) helium gas. The first wall of TBM ma...

Tuberculous meningitis (TBM) is a common entity n children and also in adults with prediosposing factors such as AIDS, alcoholism, diabetes mellitus, malignancy and use of steroids. TBM often leads to considerable morbidity and mortality. We present here CSF culture positive cases of TBM reported between 2000 and 2004 from our institution. CSF specimens from patients suspected of TBM were proce...

Safety analysis is a part of the ITER Test Blanket Module (TBM) design process to ensure that the TBM does not adversely affect the safety of ITER. To get the license for TBM as a whole with International Thermonuclear Experimental Reactor (ITER), the relevant safety analysis is required for each TBM system proposed by each party. The safety analysis for the Chinese Dual-Functional Lithium-Lead...

Practical Tunnel-boring Machine (TBM) guidance systems usually use sophisticated instruments to obtain the orientation of the TBM. These systems require frequent calibration and work shutdown, making the procedure complex and time consuming. Besides, the majority of current TBM guidance solutions cannot provide the position of the invisible cutter head analytically including commonly used laser...

To investigate the maternal-fetal transfer of tobramycin (TBM) and its distribution in the fetus, a single dose of 2 mg/kg was administered intramuscularly to 35 pregnant patients (13 first trimester, 22 second trimester) 0.5 to 34 h before hysterectomy. TBM concentration was assayed microbiologically in maternal serum, fetal tissues (placenta, brain, lung, liver, and kidney), and fluids (amnio...

BACKGROUND The incidence of cryptococcal meningitis (CM) and tuberculous meningitis (TBM) have gradually increased in recent years. These two types of meningitis are easily misdiagnosed which leads to a poor prognosis. In this study we compared differences of clinical features and prognostic factors in non-HIV adults with CM and TBM. METHODS We retrospectively reviewed the medical records of ...

OBJECTIVE To investigate the prognostic factors of tuberculous meningitis (TBM) and develop strategies for the improvement of clinical efficacy. METHODS A total of 156 TBM patients were retrospectively reviewed. The demographic characteristics, underlying diseases, clinical features, laboratory findings, bacteriologic test, images, use of steroids, mannitol and anti-TB drugs, surgery or drain...

The aim of this study was to examine the performance of T-SPOT.TB on cerebrospinal fluid (CSF) and peripheral blood (PB) in diagnosis of tuberculous meningitis (TBM) in China. Of 100 patients with presumed TBM prospectively enrolled from Sep 2012 to Oct 2014, 53 were TBM (21 definite and 32 probable TBM cases) and 37 were non-TBM cases; the other 10 patients were excluded from analysis due to i...