نتایج جستجو برای: taurine antioxidant

تعداد نتایج: 97152  

Journal: :American journal of physiology. Endocrinology and metabolism 2009
Trevor Askwith Wei Zeng Margaret C Eggo Martin J Stevens

In human Schwann cells, the role of taurine in regulating glucose-induced changes in antioxidant defense systems has been examined. Treatment with high glucose for 7 days induced reactive oxygen species, increased 4-hydroxynoneal adducts (20 +/- 5%, P < 0.05) and poly(ADP-ribosyl)ated proteins (40 +/- 13%, P < 0.05). Increases in these markers of oxidative stress were reversed by simultaneous i...

2017
M.G. Akande U.S. Ahmed

The aim of the study was to determine the effects of taurine in rats exposed to subacute dichlorvos toxicity. Fifty rats were weighed and assigned into five groups of ten rats each. The groups received: distilled water, soya oil (1 ml/kg), taurine (50 mg/kg), dichlorvos (10 mg/kg) and the combination treatment group received taurine first and then dichlorvos 30 min later. The treatments were ad...

2011
Shuyu Piao Young-Nam Cha Chaekyun Kim

Taurine chloramine is the major chloramine generated in activated neutrophils via the reaction between the overproduced hypochlorous acid and the stored taurine. Taurine chloramine has anti-inflammatory and cytoprotective effects in inflamed tissues by inhibiting the production of inflammatory mediators. Taurine chloramine increases heme oxygenase activity and also protects against hydrogen per...

2012
Svend Høime Hansen Ole Hartvig Mortensen

Taurine is a sulfur-containing amino acid, which does not enter protein synthesis, and is traditionally considered as an inert molecule without any reactive groups. Besides the well-known conjugation with bile acids, taurine has a number of other physiological functions such as, intracellular osmolyte for volume regulation and some antioxidant properties (Bouckenooghe et al., 2006; Hansen, 2001...

2013
Emily J. Berning Noah Bernhardson Kelly Coleman Dina A. Farhat Courtney M. Gushrowski Alison Lanctot Benjamin H. Maddock Kathryn G. Michels Luke A. Mugge Catherine M. Nass Sarah M. Yearsley Robert R. Miller

Because taurine alleviates ethanol- (EtOH-) induced lipid peroxidation and liver damage in rats, we asked whether exogenous taurine could alleviate EtOH-induced oxidative stress in chick embryos. Exogenous EtOH (1.5 mmol/Kg egg or 3 mmol/Kg egg), taurine (4 μmol/Kg egg), or EtOH and taurine (1.5 mmol EtOH and 4 μmol taurine/Kg egg or 3 mmol EtOH and 4 μmol taurine/Kg egg) were injected into fer...

2017
Wenhua Zhu Siwen Chen Ronggui Chen Zhiqing Peng Jun Wan Benyan Wu

BACKGROUND Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, for which there is currently no safe and effective drug for therapy. In this study, we explored the effects of taurine, tea polyphenols (TPs), or a combination thereof, on NASH rats. METHODS Rats were divided into a normal group, a high-fat diet induced model group and a treatment group (...

Journal: :Advanced pharmaceutical bulletin 2011
Mina Islambulchilar Mohammad Reza Sattari Mohammad Sardashti Farzaneh Lotfipour

CONTEXT Gentamicin is mainly used in severe infections caused by gram-negatives. However toxicity including nephrotoxicity and ototoxicity is one of the most important complications of its treatment. The production of free radicals seems to be involved in gentamicin toxicity mechanism. Taurine, a major intracellular free β-amino acid, is known to be an endogenous antioxidant. So potentially the...

2016
Jessica R. Terrill Marisa N. Duong Rufus Turner Caroline Le Guiner Amber Boyatzis Anthony J. Kettle Miranda D. Grounds Peter G. Arthur

Duchenne Muscular Dystrophy (DMD) is a fatal skeletal muscle wasting disease presenting with excessive myofibre necrosis and increased inflammation and oxidative stress. In the mdx mouse model of DMD, homeostasis of the amino acid taurine is altered, and taurine administration drastically decreases muscle necrosis, dystropathology, inflammation and protein thiol oxidation. Since the severe path...

Journal: :Investigative ophthalmology & visual science 2002
Ryo Shioda Peter S Reinach Tatsuhiro Hisatsune Yusei Miyamoto

PURPOSE To characterize in SV40-immortalized human corneal epithelial cells (tHCEC) osmosensitive taurine transporter gene and protein expression as well as its functional activity. To evaluate whether medium supplementation with taurine improves cell viability during a hypertonic challenge. METHODS tHCEC were preincubated for up to 48 hours in hypertonic DMEM medium (i.e., up to 500 mosmol/k...

2015
M. Sudha D. Rajkumar

Cardiovascular diseases form the major health concern in recent years, causing severe illness and death throughout the world. About 16.7 million people around the globe die of myocardial infarction every year (WHO 2004) which forms one third of global deaths. Clinically, taurine has been widely used in variety of conditions including cardiovasculardiseases, hypercholesterolemia, macular degener...

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