Background: Warfarin has been the mainstay oral anticoagulant agent for the last several decades despite its narrow therapeutic index. It is critical for health professionals to have better knowledge and understanding on oral anticoagulant management and on how to give counseling for patients on this therapy. This study assessed healthcare professionals’ knowledge and counseling practice on war...

BACKGROUND Uncontrolled haemorrhage is still responsible for more than 50% of all trauma-related deaths within the first 48 h after hospital admission. Clinical observations together with recent research resulted in a new appreciation of the central role of coagulopathy in acute trauma care. A synopsis of different analyses based on datasets from severely multiple-injured patients derived from ...

BACKGROUND Uncontrolled hemorrhage is responsible for over 50% of all trauma-related deaths within the first 48 hours after admission. Clinical observations together with recent research resulted in an appreciation of the central role of coagulopathy in acute trauma care. A synopsis is presented of different retrospective analyses based upon datasets from severe multiply injured patients derive...

Rationale: We recently demonstrated that proteolytic cleavage fragments of cardiac myo-sin binding protein-C (cMyBP-C) can be detected in the serum after myocardial infarction (MI) in a rat model and in patients with MI. The findings implied that serum cMyBP-C might be useful as cardiac-specific biomarker for MI. The release kinetics of cMyBP-C in the circulation post-MI remains to be elucidate...

ject of debate for many years. The effectiveness of prophylactic treatment has not been tested in controlled studies. Therefore, treatment aimed at preventing the progression of disease does not appear justified in most asymptomatic patients. With regard to the well known side effects of medical therapy in hypertrophic cardiomyopathy and a small but important risk of late sudden atrioventricula...