Aim To access the pharmacokinetics and comparative bioavailability of two tamoxifen citrate (TAM) formulations in 20 healthy Chinese male subjects under fasting conditions. Methods TAM test capsules and reference tablets were administered as a single dose on two treatment days separated by a 3-week washout period. After dosing, serial blood samples were collected for a period of 72 hr, and plas...

The present study was designed for the development of a stable sustained release liposomal drug delivery system for tamoxifen citrate (TC) using soya phosphatidylcholine (SPC), cholesterol (CH) and span 20 as main ingredients. Liposomes were prepared by formation of thin lipid film followed by hydration. The mean vesicle diameter was found to be 203.5 Â 19.5 nm with 21% of the liposomal populat...

objective: in this study, artificial neural network (ann) analysis of virotherapy in preclinical breast cancer was investigated. materials and methods: in this research article, a multilayer feed-forward neural network trained with an error back-propagation algorithm was incorporated in order to develop a predictive model. the input parameters of the model were virus dose, week and tamoxifen ci...

This paper describes a micellar liquid chromatographic method used to analyze tamoxifen (TAMO) in pharmaceutical formulations, while focusing in its interesting features. Solid samples were solved in a micellar solution, irradiated at 254 nm, filtered and injected. Extraction steps were avoided and thus expediting the procedure. Tamoxifen was resolved in <5 min, using a mobile phase containing ...

The anti-oestrogen tamoxifen is the most commonly used treatment for patients with oestrogen-receptor (ER)-positive breast cancer. Although many patients benefit from tamoxifen in the adjuvant and metastatic settings, resistance is an important clinical problem. The target of tamoxifen in vivo is the ER. Over the last decade many advances have been made in our understanding of the biology of th...