BACKGROUND To explore the effects and the mechanism of vitamin D (VD) and tacrolimus (TAC) combinatorial therapy in the treatment of IgA nephropathy (IgAN) in a rat model. MATERIAL AND METHODS IgAN rat models constructed by oral immunization with bovine serum albumin (BSA) and lipopolysaccharide (LPS) (n=30) and were treated with: saline (model group), TAC (TAC group), or TAC+VD therapy (TAC+VD...

Anti-Tac monoclonal antibody, which blocks the membrane binding and action of human T-cell growth factor (TCGF), is strongly proposed to recognize TCGF receptor. We have demonstrated that anti-Tac antibody reacted with leukemic cells from patients with adult T-cell leukemia (ATL) and reacted with T-cell lines established from ATL cells. Although antigenic modulation, or down-regulation, of Tac ...

AIM OF THE STUDY Decreased total antioxidant capacity (TAC) has been reported in different neoplasms, including lung cancer. However, no study concerning the relationship between endogenous antioxidants, lifestyle factors, and TAC has been conducted among lung cancer patients. The purpose of the study was to investigate the associations between endogenous antioxidants, severity of disease, life...

Human milk contains all of the constituents that are required for the optimal growth and development of a neonate. It supports the development of brain, immune, and physiological systems. This study aimed to consider the significance of breast milk in preventing oxidative stress by comparing total antioxidant capacity (TAC) in breast and formula milk for premature infants, demonstrating the rel...

Serum C-reactive protein (CRP) elevation predicts the development of heart failure in patients with hypertension. CRP activates macrophages and enhances oxidative stress. We hypothesize that CRP itself has a pathogenic role in the development of pressure overload-induced cardiac remodeling. Transgenic mice with human CRP overexpression (CRPtg) and nontransgenic littermates (CON) were subjected ...

Se muestran diferentes obras y proyectos relacionados con el arte sonoro, la ciudad uso de tecnologías contemporáneas. divide en introducción, metodología, resultados conclusiones. En los primero se señalan conocidas que sirven antecedentes a siguientes mostrando tradicional reunión este género lo tecnológico. Después abordan las núcleo del texto avanzando desde internet Tecnologías Información...

The study attempted to clarify the role of total antioxidant capacity of seminal plasma (SP-TAC) on boar sperm survival and fertility after artificial insemination (AI). SP-TAC differed (P < 0.001) among boars (n° = 15) and, to a lesser degree, among ejaculates within male (4 ejaculates/boar). SP-TAC also differed (P < 0.001) among ejaculate fractions (43 ejaculates and 3 fractions per ejaculat...

BACKGROUND The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the UPS. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and androgen receptor (AR) have been reported to be mediators of CMP and he...

The Two-Way Task: Run1: TAC-M, TS-M, and Tri-BM Run2: TAC-M, TS-M, and BoW-BM Run3: TAC-M, TS-M, NE-M, & Tri-BM, BoW-BM The Three-Way Task: Run1: TAC-M, TS-M, and Tri-BM, BoWBM Run2: TAC-M, TS-M, NE-M (partial), and Tri-BM, BoW-BM Run3: TAC-M, TS-M, NE-M, and Tri-BM, BoW-BM From Two-Way to Three-Way: If BoW-BM=YES & Tri-BM=NO then CONTRADICTION If BoW-BM=YES & Tri-BM=YES then ENTAILMENT Others ...