A T4 suppression test involving 24-h thyroidal 131I uptake was carried out on patients with Graves' disease during therapy with an antithyroid drug. Thirty-three patients received propylthiouracil (PTU) for at least 1 year. Each patient was given 75 micrograms L-T3 daily for 8 days in conjunction with PTU (50 mg/day) at the time of the experiment and then the 24-h thyroidal 131I uptake (post T3...

Dear Editor, There is substantial degree of disagreement regarding the mechanisms of possible association between thyroid dysfunction and Alzheimer’s disease. For example, it is not settled which indicator of thyroid function is the best marker of this relationship. Since thyroid disorders could be considered as treatable risk factors for Alzheimer’s disease, identification of any relationship ...

We have recently reported that the entry of 3,3',5-triiodo-L-thyronine (T3) into mouse 3T3 fibroblasts occurs by receptor-mediated endocytosis (Cheng, S. Y., Maxfield, F. R., Robbins, J., Willingham, M. C., and Pastan, I. (1980) Proc. Natl. Acad. Sci. U. S. A. 77: 3425-3429). In this communication, we evaluated the functional significance of this mode of entry using GH3 cells, a growth hormone-...

statement of problem: since the fluoride releases from materials with the property of releasing fluoride are decreasing gradually, it seems that probably the material rechargeability is more important than their long-term fluoride release. purpose: the objective of this study was to asses the fluoride release and rechargeability of 2 types of fluoride releasing restorative materials, a resin mo...

Serum concentration of FSH, LH, testosterone, prolactin, ACTH, cortisol, TSH, T4, T3 and resin T3 uptake were measured in 146 men who were exposed to vesicants used by the Iraqi regime a few days t04 weeks prior to testing. Clinical and laboratory findings had confirmed the use of mustard gas. Mean serum concentrations of FSH, LH, TSH and prolactin were not significantly different from no...

The uptake of [125I]triiodothyroacetic acid ([125I]Triac) in anterior pituitary cells was investigated and compared with that of [125I]T3. Furthermore, the effects of Triac, T3, and T4 on TSH release were compared. Cells isolated from adult male Wistar rats were cultured for 3 days in medium with 10% fetal calf serum. Uptake was measured at 37 C with [125I]Triac (100,000 cpm; 120 pM) or [125I]T...

Whether Na+ movement through the plasma membrane plays a role in thyroid hormone uptake was investigated in intact rat soleus muscles. After preincubation for 120 min at 37 degrees C in modified Krebs-Ringer bicarbonate containing 140 or 5 mM Na+ plus choline or lithium to maintain osmolarity, muscles were incubated with 50 pM [125I]triiodo-L-thyronine (T3) or [125I]L-thyroxine (T4) for 60 min....

We compared the specificities of transport mechanisms for uptake and efflux of thyroid hormones in cells of the human choriocarcinoma cell line, JAR, to determine whether triiodothyronine (T3), thyroxine (T4) and reverse T3 (rT3) are carried by the same transport mechanism. Uptake of 125I-T3, 125I-T4 and 125I-rT3 was saturable and stereospecific, but not specific for T3, T4 and rT3, as unlabell...

 Abstract Background: The thyroid hormones influence on all metabolic pathways. After heart surgery using cardiopulmonary bypass (CPB), serum T3 decreases and remains low for at least 24 hours. Several studies on pediatric have reported reduction of thyroid hormones after heart surgery. This study aimed to investigate the status of thyroid function tests in children with CPB surgery. Metho...

serum concentration of fsh, lh, testosterone, prolactin, acth, cortisol, tsh, t4, t3 and resin t3 uptake were measured in 146 men who were exposed to vesicants used by the iraqi regime a few days t04 weeks prior to testing. clinical and laboratory findings had confirmed the use of mustard gas. mean serum concentrations of fsh, lh, tsh and prolactin were not significantly different from normal v...