Normal human urothelium and tumors of urothelial origin were ana lyzed with a panel of seven mouse monoclonal antibodies that identify surface antigens of cultured bladder cancer cell lines. Three categories of antigens were defined on the basis of differential expression on normal urothelium versus bladder tumors. Om5 (a category 1 antigen) is a highly restricted, differentiation antigen detec...

DNAzymes are known to bind metal ions specifically to carry out catalytic functions. Despite many studies since DNAzymes were discovered nearly two decades ago, the metal-binding sites in DNAzymes are not fully understood. Herein, we adopt uranyl photocleavage to probe specific uranyl-binding sites in the 39E DNAzyme with catalytically relevant concentrations of uranyl. The results indicate tha...

The kinetics of alkane cracking in zeolites MFI and FAU have been simulated theoretically from first principles. The apparent rate coefficient for alkane cracking was described as the product of the number of alkane molecules per unit mass of zeolite that are close enough to a Brønsted-acid site to be in the reactant state for the cleavage of a specific C-C bond and the intrinsic rate coefficie...

OBJECTIVES I tested a social marketing intervention delivered in health department waiting rooms via digital signage technology for increasing radon program participation among priority groups. METHODS I conducted a tri-county, community-based study over a 3-year period (2010-2013) in a high-radon state by using a quasi-experimental design. We collected survey data for eligible participants a...

Although variants in many genes have previously been shown to be associated with blood pressure (BP) levels, the molecular mechanism underlying these associations are mostly unknown. We identified a multi-allelic T-rich sequence (TRS) in the 3'UTR of ATP1B1 that varies in length and sequence composition (T22-27 and T12GT 3GT6). The 3'UTR of ATP1B1 contains 2 functional polyadenylation signals a...

Pipecolic acid (4) (Fig. 6 ), an imino acid oc­ curring in plants 1, animals 2> 3, and microorgan­ isms 4, is known to be a product of lysine cata­ bolism. Tracer studies have shown that lysine labelled in different positions is incorporated into pipecolic acid in such diverse organisms as Phaseolus sp. 5) 6, Triticum sp . 7, Zea m a y s8, Acacia hom alophylla9, Leucaena glauca10, Mimosa pudic ...

Doubled haploid (DH) populations, particularly those from subspecies crosses possessing the wide compatible gene S5n , are important germplasm resources for rice genetic studies and breeding, but their feature and potential have not been fully assessed and explored. In the present study, we produced a DH population from the hybrid of japonica 668B and wide compatible indica T23. Genotyping of t...