نتایج جستجو برای: t regulatory cells treg

تعداد نتایج: 2028555  

Journal: :iranian journal of allergy, asthma and immunology 0
afshin amari department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran. massoumeh ebtekar department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran. seyedmohammad moazzeni department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran. masoud soleimani department of hematology, faculty of medical science, tarbiat modares university, tehran, iran and department of stem cells biology, stem cell technology research center, tehran, iran. leila mohammadi-amirabad department of medical genetics, national institute of genetic engineering and biotechnology, tehran, iran. mohammadtaher tahoori department of immunology, faculty of medicine, shahid sadoughi university of medical sciences, yazd, iran.

human wharton’s jelly-derived mesenchymal stem cells (hwj-mscs) are easily available cells without transplant rejection problems or ethical concerns compared to bone-marrow-derived mscs for prospective clinical applications. these cells display immunosuppressive properties and may be able to play an important role in autoimmune disorders. regulatory t-cells (treg) are important to prevent autoi...

2016
Tzu-Yu Shao Ling-Hui Hsu Chien-Hui Chien Bor-Luen Chiang

Recent studies have revealed various Foxp3(-) regulatory T (Treg) cell subsets effectively protect mice from colitis. In the present study, we demonstrated that B cells induced a particular subset of regulatory T (Treg-of-B) cells, expressing programmed cell death 1 (PD-1), inducible costimulator (ICOS), lymphocyte-activation gene 3 (LAG3), glucocorticoid-induced tumor necrosis factor receptor ...

Journal: :International journal of clinical and experimental pathology 2013
Ping Wang Song Guo Zheng

The regulatory T (Treg) cells play an important role in the maintenance of homeostasis and the prevention of autoimmune diseases. Although most studies are focusing on the role of Treg cells in T cells and T cells-mediated diseases, these cells also directly affect B cells and other non-T cells. This manuscript updates the role of Treg cells on the B cells and B cell-mediated diseases. In addit...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Alice McNally Geoffrey R Hill Tim Sparwasser Ranjeny Thomas Raymond J Steptoe

CD4(+)CD25(+) regulatory T cells (Treg) play a crucial role in the regulation of immune responses. Although many mechanisms of Treg suppression in vitro have been described, the mechanisms by which Treg modulate CD8(+) T cell differentiation and effector function in vivo are more poorly defined. It has been proposed, in many instances, that modulation of cytokine homeostasis could be an importa...

2006
Markus G. Seidel Ursula Ernst Dieter Printz Birgit Juergens Josefa Pichler Andishe Attarbaschi Gerhard Fritsch Helmut Gadner Andreas Heitger

CD4 CD25 T cells have been implicated in two apparently opposing functions, namely an activated effector function but also a regulatory function. In human hematopoietic stem cell transplantation (HSCT), the frequency of CD4CD25 T cells is increased and this increase was reported to correlate with graft-versus-host disease (GvHD), suggesting that the effector function predominates. In mice, CD4C...

Journal: :Blood 2007
Jan Kubach Petra Lutter Tobias Bopp Sabine Stoll Christian Becker Eva Huter Christoph Richter Petra Weingarten Tobias Warger Jürgen Knop Stefan Müllner John Wijdenes Hansjörg Schild Edgar Schmitt Helmut Jonuleit

CD4(+)CD25(+)Foxp3(+) regulatory T cells (CD25(+) Treg cells) direct the maintenance of immunological self-tolerance by active suppression of autoaggressive T-cell populations. However, the molecules mediating the anergic state and regulatory function of CD25(+) Treg cells are still elusive. Using differential proteomics, we identified galectin-10, a member of the lectin family, as constitutive...

Journal: :Infectious disorders drug targets 2008
Rolando Vernal Jose A Garcia-Sanz

In addition to the T helper 1 (Th1) and Th2 lymphocyte subsets, two new subpopulations Th17 and regulatory T (Treg) cells have recently been described. Th17 cells, which produce high levels of interleukin (IL)-17, are dependent on the transcription factor orphan nuclear receptor RORC2/RORgammat and have been implicated in exacerbating the immune response to infections. Conversely, Treg cells, e...

Journal: :Investigative ophthalmology & visual science 2010
Sunao Sugita Shintaro Horie Yukiko Yamada Hiroshi Keino Yoshihiko Usui Masaru Takeuchi Manabu Mochizuki

PURPOSE To determine whether iris pigment epithelium (IPE)-induced T regulatory (Treg) cells can suppress the activation of bystander T cells with cell contact via costimulatory interactions. METHODS CD8(+) T cells were cocultured with IPE, x-irradiated, and then used as regulators (IPE-induced Treg cells). The target CD4(+) T cells from wild-type control or knockout donors were used for the ...

Journal: :Journal of immunology 2005
Hideaki Sugiyama Rolland Gyulai Eiko Toichi Edina Garaczi Shinji Shimada Seth R Stevens Thomas S McCormick Kevin D Cooper

The balance between regulatory and effector functions is important for maintaining efficient immune responses, while avoiding autoimmunity. The inflammatory skin disease psoriasis is sustained by the ongoing activation of pathogenic effector T cells. We found that a CD4(+) T lymphocyte subpopulation in peripheral blood, phenotypically CD25(high), CTLA-4(+), Foxp3(high) (regulatory T (Treg) cell...

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