OBJECTIVE There are few reports investigating the potential benefits of preoperative systemic chemotherapy for patients with node-positive upper tract urothelial carcinoma. The purpose of this study was to examine the impact of preoperative systemic chemotherapy on the clinical outcomes of patients with node-positive upper tract urothelial carcinoma treated by radical nephroureterectomy. METH...

Background: Primary treatment for gastric cancer with peritoneal dissemination is systemic chemotherapy because the effectiveness of cytoreductive surgery remains unclear. This study aimed to investigate the efficacy of cytoreductive surgery with systemic chemotherapy for advanced gastric cancer with peritoneal dissemination. Methods: From 2007 to 2014, 40 patients with peritoneal disseminated ...

PURPOSE To identify the role of systemic chemotherapy in the management of appendiceal malignancies. METHODS Over a 10-year period (2005 -2014), 52 patients with appendiceal neoplasms were treated at our Peritoneal Surface Malignancy Unit [14 (26.9%) disseminated peritoneal adenomucinosis (DPAM), 30 (57.7%) peritoneal mucinous carcinomatosis of appendiceal origin (PMCA) and 8 (15.4%) PMCA-I]....

Chemotherapy is used to treat numerous cancers including melanoma. However, its effectiveness in clinical settings is often hampered by various mechanisms. Previous studies have demonstrated that prooxidative stressor-mediated generation of oxidized lipids with platelet-activating factor-receptor (PAF-R) agonistic activity induces systemic immunosuppression that augments the growth of experimen...

PURPOSE The objective was to determine predictive factors for premature discontinuation of docetaxel-based systemic chemotherapy in men with castration-resistant prostate cancer (CRPC). MATERIALS AND METHODS We retrospectively reviewed the medical records of men who were treated with docetaxel-based systemic chemotherapy for CRPC in a single institution between May 2005 and April 2010. After ...

AIM To characterize patients with gastric peritoneal carcinomatosis (PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care. METHODS We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a s...

Objective: We report an extremely rare case of granulocytic sarcoma in bilateral temporal bones. Methodology: Case report and a review of related literature. Results: The patient was initially performed neoplasm ectomy then systemic chemotherapy in his left ears. After surgery the patient got a significant improvement of his left hearing. One year later systemic chemotherapy was established aga...

4080 Background: Peritoneal carcinomatosis due to high-grade appendiceal neoplasm is optimally treated with cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) in selected patients. Systemic chemotherapy is often administered either prior or after surgery utilizing the same regimens applied in advanced colon cancer despite the very limited data to support such approach. ...

Primary systemic therapy (PST) or neoadjuvant therapy is used in nonmetastatic breast cancer to treat systemic disease earlier, decrease tumor bulk ideally to a complete pathological response (pCR), and reduce the extent of surgery. The multitude of clinical trials using PST in breast cancer patients has not proven the fundamental hypotheses of improved overall survival and disease-free surviva...

Chemotherapy and targeted therapies are effective palliative options for numerous unresectable or metastatic cancers. However, treatment resistance inevitably develops leading to mortality. In a subset of patients, systemic therapy appears to control the majority of tumors leaving 5 or less to progress, a phenomenon described as oligoprogression. Reasoning that the majority of lesions remain re...