The history of specific therapy for hereditary tumors dates back to mid 1980s and involves a number of reports demonstrating regression of familial colon polyps upon administration of sulindac. Virtually no clinical studies on other hereditary cancer types were available until the year 2009, when Byrski et al. presented the data on unprecedented sensitivity of BRCA1-associated breast malignanci...

Introduction: Very low, Low and Medium X-ray machines are used extensively for Superficial Radiation Therapy mostly used for Basal Cell, Squamous Cell Carcinoma, and Melanoma skin cancers. In most of cases, Superficial X-ray Therapy (SXRT) is preferred to Electron beams generated using a linear accelerator. SXRT tube characteristics may vary with the use of the machine for a lo...

Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...

T he emerging view is that many cancers, due to present therapeutics, may become chronic diseases that need to be managed over many years with diet, lifestyle, and environment changes.'-^ Management of the patient that is appropriate for the stage of his or her disease is dependent upon the availability of biomarkers or screening tests that have been validated to define the status ofthe individ...

The emerging view is that many cancers, due to present therapeutics, may become chronic diseases that need to be managed over many years with diet, lifestyle, and environment changes. Management of the patient that is appropriate for the stage of his or her disease is dependent upon the availability of biomarkers or screening tests that have been validated to define the status of the individual...

Nanoparticles have shown marked promise as both antineoplastic agents and drug carriers. Despite strides made in immunomodulation, low success rates toxicity remain limitations within the clinical oncology setting. In present review, we assess advances delivery nanoparticles, for systemic topical use, skin cancer treatment. A systematic review of controlled trials, meta-analyses, Cochrane artic...

Cancers of the salivary glands are unusual lesions that vary widely in their histologic appearance and molecular characteristics. Likewise, there is a wide spectrum of biologic behavior, ranging from low-grade, minimally invasive tumors, to highly lethal malignancies. There are few data on the role of systemic therapies in the management of these cancers, and chemotherapy is generally reserved ...

BACKGROUND In patients with advanced-stage cancer, systemic thrombolysis with tissue plasminogen activator (tPA) for hyperacute ischemic stroke is not strictly off-label, but it is at higher risk of complications (including bleeding). CASE REPORT A 71-year-old male with unrecognizable malignancy developed a hemispheric ischemic stroke and received intra-venous tPA within 4.5 h of onset, follo...