Synthetic cell therapy is a field that has broad potential for future applications in human disease treatment. Next generation therapies will consist of engineered bacterial strains capable of diagnosing disease, producing and delivering therapeutics, and controlling their numbers to meet containment and safety concerns. A thorough understanding of the microbial ecology of the human body and th...

Since the 1970s, the limitations of two dimensional (2D) cell culture and the relevance of appropriate three dimensional (3D) cell systems have become increasingly evident. Extensive effort has thus been made to move cells from a flat world to a 3D environment. While 3D cell culture technologies are meanwhile widely used in academia, 2D culture technologies are still entrenched in the (pharmace...

Although recurrent unprovoked seizures or epilepsy has been known for more than three thousand years, and even considering pivotal contributions like that of Hypocrates (circa 400 BC) establishing epilepsy as a brain disease instead of a religious or evil phenomenon, it was not until the 20th century that the first relatively effective antiepileptic drugs were discovered. Starting from phenobar...