background: salivary gland tumors (sgt) are rare lesions with uncertain histopathology. one of the major signaling pathways that participate in the development of several tumors is protein kinase a. in this pathway, glycogen synthase kinase β (gsk3β) and camp responsive element binding protein (creb3) are two genes which are supposed to be down regulated in most human tumors. the expression lev...

nitric oxide (no) is thought to be involved in spatial learning and memory in several brain areas such as hippocampus. this study examined the effects of post-training intrahippocampal microinjections of 1400w as a selective inos inhibitor on spatial memory, in anesthetized and non-anesthetized situations in rats. in the present work, 4-day training trials of animals were conducted. spatial mem...

dracocephalum kotschyi (lamiaceae), as one of the remarkable aromatic plants, widely grows and also is cultivated in various temperate regions of iran. there are diverse reports about the composition of the oil of this plant representing limonene derivatives as its major compounds. there is no report on cloning of mono- or sesquiterpene synthases from this plant. in the present study, the aroma...

introduction: polymorphism in genes involved in folate metabolism may cotribute to the susceptibility to acute lymphoblastic leukemia (all). patients and methods : to examine the influence of polymorphism in thymidylate synthase (ts 28-bp repeat) and methionine synthase (ms a2756g) genes on the susceptibility to all, 73 children with all and 128 age and gender matched, unrelated healthy individ...

Dracocephalum kotschyi (Lamiaceae), as one of the remarkable aromatic plants, widely grows and also is cultivated in various temperate regions of Iran. There are diverse reports about the composition of the oil of this plant representing limonene derivatives as its major compounds. There is no report on cloning of mono- or sesquiterpene synthases from this plant. In the present study, ...

Heterozygosity is the major constraint in perennial fruit crop like mango for regular bearing breeding. Majority of popular varieties have irregular habit. Many external and internal factors affect habit crops. Among factors, level carbohydrate reserves phytohormones plays a role on crops apple, citrus, mango, litchi etc., Therefore, present research work aimed to study metabolism pathways geno...

Two chaperones, Atp23p and Atp10p, were previously shown to regulate the assembly of yeast mitochondrial ATP synthase, extra expression ATP23 was found partially rescue an atp10 deletion mutant, by unknown mechanism. Here, we identified that residues 112-115 (LRDK) required for its function in assisting demonstrated both functions Atp23p, processing subunit 6 precursor partial mutant. By chasin...

Certain species of pathogenic bacteria damage tissues by secreting cholesterol-dependent cytolysins, which form pores in the plasma membranes animal cells. However, reducing cholesterol protects cells against these cytolysins. As first committed step biosynthesis is catalyzed squalene synthase, we explored whether inhibiting this enzyme protected We synthesized 22 different nitrogen-containing ...