The growth and survival of cancer cells are greatly related to their surrounding microenvironment. To understand the regulation under the impact of anti-cancer drugs and their synergistic effects, we have developed a multiscale agent-based model that can investigate the synergistic effects of drug combinations with three innovations. First, it explores the synergistic effects of drug combinatio...

A fundamental feature in the action of most mitogenic agents when added to quiescent cells in serum-free medium is that they exhibit striking synergistic effects when applied in specific combinations. A tenable hypothesis of growth control must provide a cogent explanation for the molecular mechanisms underlying this complex pattern of synergistic effects. To gain an understanding of the mechan...

Mechanoluminescence (ML) has become the most promising material for broad applications in display and sensing devices, which ZnS is commonly studied one due to its stable highly repetitive ML performances. In this work, we have successfully prepared biphase on a large scale through facile in-air molten salt protection strategy. The obtained best properties, mainly attributed synergistic effects...

the aim followed in the present study was to evaluate the antioxidant activity of individual vs. combined extracts of rosemary leaves and oak fruit to detect the possible interactions in their antioxidant activity following combination and in order to find a way to use oak fruit natural antioxidants as an available massive source in iran. towards this end, methanolic extracts of rosemary and oa...

purpose: to report and review a rare variant of duane's syndrome named synergistic divergence and its surgical results. patient and findings: a 16-year-old girl presented with left face turn and reduced vision in both eyes. best corrected vision was od: 3/10 and os: 10/10. there was severe adduction deficiency of the re with simultaneous abduction of the re in left gaze. she had xt= 35 in ...