Background and aim: Cleft lip and cleft palate are among the most common orofacial abnormalities. Patients with these deformities commonly present with midface deficiency and need challenging treatment modalities that focus on improving the position of the maxilla. Tongue plate appliance is an intraoral device that has shown promising results in the treatment of growing patients with maxillary ...

This article discusses monozygotic twin patients with Van der Woude syndrome, the most common form of syndromic cleft lip and palate, who have concordant manifestations. The syndrome has an autosomal dominant hereditary pattern with variable expressivity and a high degree of penetrance with clinical features, including lower lip sinuses with a cleft lip, cleft palate, or both. Some mutations ha...

Orofacial clefts (OFC; MIM 119530) are among the most common major birth defects. Here, we carried out mutation screening of the PVR and PVRL2 genes, which are both located at an OFC linkage region at 19q13 (OFC3) and are closely related to PVRL1, which has been associated with both syndromic and non-syndromic cleft lip and palate (nsCLP). We screened a total of 73 nsCLP patients and 105 non-cl...

BACKGROUND Mutations of the MSX1 gene may contribute to non-syndromic forms of cleft lip and/or cleft palate. AIM To search for mutations of MSX1 coding regions, including one highly conserved non-coding region in the single intron, among Chilean patients with cleft lip/palate. PATIENTS AND METHODS We studied 45 patients with cleft lip/palate and their parents. Oral mucosa samples were obta...

Cleft lip and cleft palate (CL/P) is a deformity indicated by an opening or uncommon in the roof of the mouth (palate). The differences in ethnicity, gender, correlation with genetic factors influence prevalence Non-syndromic CL/P. This study was conducted through literature review on genes that were allegedly associated Genetics play role, to greater lesser extent, all diseases. Besides, pal...

The aetiology of non-syndromic cleft lip with or without cleft palate (NSCL/P) is complex involving multiple interacting genes and environmental factors. The primary objective of the present study was to investigate the role of TFAP2A gene single nucleotide polymorphisms (SNPs) in the pathogenesis of NSCL/P. In this study, 173 unrelated NSCL/P patients and 176 controls without clefts were genot...

BACKGROUND The aim of this study was to investigate the risk of psychiatric diagnoses in individuals with non-syndromic oral clefts (OC) compared with individuals without OC, including ages from 1 to 76 years. METHODS Linking four Danish nationwide registers, we investigated the risk of psychiatric diagnoses at Danish psychiatric hospitals during the period 1969-2012 for individuals born with...

The aim of this study was to evaluate the prevalence cleft lip and/or palate (CL/P) and associated factors in patients treated at a referral service Brazil's Midwest. Data were obtained from medical records on file between 2010 2017 for epidemiologic associational study. A descriptive analysis sociodemographic clinical data carried out, after which analyzed using chi-square test Poisson regress...

Problems with oral feeding occur in varying degrees in infants born with cleft lip/palate and/or craniofacial syndromes. The extent of clefting is associated with the severity of feeding problems, and if cleft lip/palate occurs in conjunction with a craniofacial syndrome, additional structural, airway, and neuromotor issues may be present. The infant's feeding and swallowing skills may be signi...