نتایج جستجو برای: swds

تعداد نتایج: 122  

2013
Ali Moghimi Samaneh Mollazadeh Fatemeh Behnam Rassouli Reza Shiee Mohammad Ali Khalilzade

INTRODUCTION Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. METHODS For EEG study, electrodes were inserted into the cortex of animals according to paxinos...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Jeanne Tamar Paz Jean-Michel Deniau Stéphane Charpier

Absence seizures are characterized by impairment of consciousness associated with bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG), which reflect paroxysmal oscillations in thalamocortical networks. Although recent studies suggest that the subthalamic nucleus (STN) provides an endogenous control system that influences the occurrence of absence seizures,...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Seung Eun Lee Jaekwang Lee Charles Latchoumane Boyoung Lee Soo-Jin Oh Zahangir Alam Saud Cheongdahm Park Ning Sun Eunji Cheong Chien-Chang Chen Eui-Ju Choi C Justin Lee Hee-Sup Shin

Intrinsic burst and rhythmic burst discharges (RBDs) are elicited by activation of T-type Ca(2+) channels in the thalamic reticular nucleus (TRN). TRN bursts are believed to be critical for generation and maintenance of thalamocortical oscillations, leading to the spike-and-wave discharges (SWDs), which are the hallmarks of absence seizures. We observed that the RBDs were completely abolished, ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Eunji Cheong Yihong Zheng Kyoobin Lee Jungryun Lee Seongwook Kim Maryam Sanati Sukyung Lee Yeon-Soo Kim Hee-Sup Shin

Absence seizures are characterized by cortical spike-wave discharges (SWDs) on electroencephalography, often accompanied by a shift in the firing pattern of thalamocortical (TC) neurons from tonic to burst firing driven by T-type Ca(2+) currents. We recently demonstrated that the phospholipase C beta4 (PLCbeta4) pathway tunes the firing mode of TC neurons via the simultaneous regulation of T- a...

2013
Mathilde Chipaux Laurent Vercueil Anna Kaminska Séverine Mahon Stéphane Charpier

Absence seizures are caused by brief periods of abnormal synchronized oscillations in the thalamocortical loops, resulting in widespread spike-and-wave discharges (SWDs) in the electroencephalogram (EEG). SWDs are concomitant with a complete or partial impairment of consciousness, notably expressed by an interruption of ongoing behaviour together with a lack of conscious perception of external ...

Journal: :European journal of neurology 2015
C L Bassetti L Ferini-Strambi S Brown A Adamantidis F Benedetti O Bruni C Cajochen L Dolenc-Groselj R Ferri S Gais R Huber R Khatami G J Lammers P H Luppi M Manconi C Nissen L Nobili P Peigneux T Pollmächer W Randerath D Riemann J Santamaria K Schindler M Tafti E Van Someren T C Wetter

In recent years, evidence has emerged for a bidirectional relationship between sleep and neurological and psychiatric disorders. First, sleep-wake disorders (SWDs) are very common and may be the first/main manifestation of underlying neurological and psychiatric disorders. Secondly, SWDs may represent an independent risk factor for neuropsychiatric morbidities. Thirdly, sleep-wake function (SWF...

Journal: :Indian journal of experimental biology 1999
P Shantilal J David T Joseph

Sodium valproate (VPA) and flunarizine (FLU) administered individually and together were examined for their effects on behavioural, and EEG changes in the pentylenetetrazole (PTZ) induced rat model of absence seizures. PTZ, 20 mg/kg, i.p., produced behavioural staring and immobility with concomitant, repetitive 7 to 9 Hz spike/wave discharges (SWDs) in EEG, monitored continuously for 1 hr and t...

Journal: :Seizure 2010
Marco Bortolato Roberto Frau Marco Orrù Mauro Fà Christian Dessì Monica Puligheddu Luigi Barberini Giuliano Pillolla Lorenzo Polizzi Federico Santoni Giampaolo Mereu Francesco Marrosu

Rich evidence has highlighted that stimulation of gamma-amino-butyric acid (GABA)(B) receptors increases the occurrence of spike-and-wave discharges (SWDs), the electroencephalographic (EEG) landmark of absence epilepsy (AE). Recent findings suggest that the outcomes of GABA(B) activation in vivo are contingent on the chemical characteristics of the agonist. In particular, the endogenous ligand...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
R Staak H C Pape

The contribution of GABAergic mechanisms in thalamic relay nuclei to spike and wave discharges (SWDs) during spontaneous seizures was assessed using the WAG/Rij strain of rats, an established genetic model of absence epilepsy, in combination with single-unit recordings and microiontophoretic techniques in the ventrobasal thalamic complex in vivo. Spontaneous SWDs occurring on the electroencepha...

2014
Weiping He David Hung-Chang Du

Shingled Write Disks (SWDs) increase the storage density by writing data in overlapping tracks. Consequently, data cannot be updated freely in place without overwriting the valid data in subsequent tracks if any. A write operation therefore may incur several extra read and write operations, which creates a write amplification problem. In this paper, we propose several novel static Logical Block...

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