Previous in vivo studies have shown that delta 9-tetrahydrocannabinol (THC), the principal active ingredient in marijuana, can suppress both luteinizing hormone (LH) and growth hormone (GH) secretion after its injection into the third ventricle of conscious male rats. The present studies were designed to determine the mechanism of these effects. Various doses of THC were incubated with either s...

The suppressive effect of (–)-epigallocatechin gallate (EGCG), the major polyphenolic constituent present in green tea, on aflatoxin B1 (AFB1)-induced chromosome aberrations (CA) in rat bone marrow cells was studied. The administration of EGCG 24 hr before the AFB1 injection significantly suppressed AFB1-induced CA. The suppression was observed 18 hr, 24 hr and 48 hr after the AFB1 treatment bu...

The analgesic mechanism of morphine on the spinal nociceptive transmission was compared in rabbits with the intact and cold-blocked states of the spinal cord. The degree of the suppressive effect of morphine (2 mg/kg) on the bradykinin-induced activity was significantly greater in the intact than in the cold-blocked states. Morphine (4 mg/kg) suppressed the nociceptive responses to similar leve...

T-cell clones generated from both CD4+CD25+ and CD8+CD25+ human thymocytes were assessed for their ability to suppress the proliferative response to allogeneic stimulation of type 1 T-helper (Th1) or type 2 T-helper (Th2) clones derived from autologous CD4+CD25- thymocytes. Both CD4+ and CD8+ T-regulatory (Treg) cells completely suppressed the proliferation of Th1 clones but exhibited significa...