Hydrophilic poly(ethylene glycol) diacrylate (PEGDA) hydrogel surfaces resist protein adsorption and are generally thought to be unsuitable for anchorage-dependent cells to adhere. Intriguingly, our previous findings revealed that PEGDA superporous hydrogel scaffolds (SPHs) allow anchorage of bone marrow derived human mesenchymal stem cells (hMSCs) and support their long-term survival. Therefor...

Engineering a cell-based keratoprosthesis often requires a struggle between two essential parameters: natural 3-D biological adhesion and mechanical strength. A novel hybrid scaffold of natural and synthetic materials was engineered to achieve both cell adhesion and implantable strength. This scaffold was characterized in terms of cell adhesion, cell migration, swelling, and strength. While the...

In this study, new antimicrobial hydrogels were prepared via reaction of functionalized-tragacanthgum (TG) biopolymer by quaternary ammonium functionalization of TG (QTG) with acrylic acid(AA). Characterization of the QTG hydrogels (QTG-AA) was carried out by FTIR,thermogravimetric analysis (TGA), and 1H NMR. Dynamic mechanical analysis, (DMA) wasconducted to characteriz...

The aim of the present controlled clinical study was to compare the clinical response of grafting superporous hydroxyapatite (HAp) granules to superporous HAp blocks in the treatment of human intrabony periodontal defects. Twenty interproximal intrabony osseous defects in 20 healthy, non-smoking subjects diagnosed with chronic periodontitis were included in this study. These twenty subjects wer...

New antimicrobial hydrogels were prepared via reaction of functionalized-Tragacanth Gum biopolymer by glycidyltrimethylammonium chloride (QTG) with acrylamide (AM). Characterization of the QTG hydrogels with AM (QTG-AM) was carried out by thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), and 1HNMR. Swelling behaviour of the QTG hydrogels was investigated on the p...

   The objective of the present study is to develop and investigate the swelling behavior of pH-sensitive Superporous Hydrogel (SPH) and SPH composite (SPHC). A novel superporous hydrogel containing poly (methacrylic acid-co-acrylamide) was synthesized from methacrylic acid and acrylamide through the aqueous solution polymerization, using N,N-methylenebisacrylamide as a crosslinker and ammonium...

Objective(s): One of the main constraints of collagen hydrogel scaffolds for using in tissue engineering is mechanical weakness. Plastic compression (PC) is a physical method to overcome the mechanical limitation of collagen hydrogel. Materials and Methods: In this study, the effects of pH on mechanical and biological properties of PC hydrogels were investigated. Collagen hydrogels were fabrica...

   The objective of the present study is to develop and investigate the swelling behavior of pH-sensitive Superporous Hydrogel (SPH) and SPH composite (SPHC). A novel superporous hydrogel containing poly (methacrylic acid-co-acrylamide) was synthesized from methacrylic acid and acrylamide through the aqueous solution polymerization, using N,N-methylenebisacrylamide as a crosslinker and ammonium...

Hydrogels are introduced to modem medicine as novel materials suitable for a variety ofbiomedical applications. Studying hydrogels as novel biomaterials has become a fast-developingand exciting research field during the last two decades. These interesting biomaterials have found awide range of application including contact lenses, vehicles for drug delivery and scaffold in tissueengineering and...

     In this research, hydrogels based on poly vinyl alcohol and poly acrylic acid blend were prepared which were cross-linked by applied thermal conditions. Afterward, effects of time and heating on water uptake were investigated. The highest water uptake value exhibited by the sample that was heated for 20 min. at 110 ºC was about 2129% after 4 days at equilibrium state. Hydrogels exhibited p...