To evaluate the efficacy of itraconazole capsules in prophylaxis for fungal infections in neutropenic patients, we conducted a prospective, double-blind, placebo-controlled, randomized trial. Patients with hematologic malignancies or those who received autologous bone marrow transplants were assigned either a regimen of itraconazole (100 mg orally twice daily; n=104) or of placebo (n=106). Over...

Medically important fungal infections can be broadly classified into superficial surface infections and invasive mycoses (Samaranayake and MacFarlane, 1990; Roemer and Krysan, 2014). Superficial surface infections include mucosal candidiasis, dermatophyte infections whereas invasive mycoses affect sterile body sites such as bloodstream, central nervous system, kidney, lungs, and liver. Rise of ...

Fungal infections in humans range flom superficial and cutaneous (such as dermatophytoses) to deeply invasive and dissemi hated (such as candidiasis and cryptococcosis). Pathogenic fungi occur worldwide, although particular species may predominate in certain geographic areas. In the past 20 years, fungal infections have increased dramatically--paradoxically, as a resuh of medical advances. Fung...

Fungal infections of the skin and nails are common global problems with attendant morbidity among affected individuals. Children are mostly affected due to predisposing factors such as overcrowding and low socioeconomic factors. The aim of this study was to determine the prevalence and the clinical patterns of superficial fungal infections among primary school children in Ile-Ife. A multistage ...

BACKGROUND Dermatophytes are the most common cause of superficial fungal infections in humans. Deep dermatophytosis, however, is rare, described to date only in isolated case reports, usually in the setting of systemic immunosuppression. OBJECTIVE To present the 15-year experience of a tertiary dermato-mycology clinic with the diagnosis and treatment of deep dermatophytosis. METHODS Patient...

Prevalence of superficial and systemic mycoses has increased in recent years. The most common etiological factors responsible for those infections are fungi of the genus Candida, mainly Candida albicans; however approximately 35–65% of candidemia cases are caused by other species of this particular genus, described in literature as Candida non-albicans pathogens. Fungal infections have deleteri...

Systemic and superficial fungal infections are a major problem among immunocompromised patients with hematological malignancy. A double-blind, double-placebo, randomized, multicenter trial was performed to compare the efficacy and safety of itraconazole oral solution (2.5 mg/kg of body weight twice a day) with amphotericin B capsules (500 mg orally four times a day) for prophylaxis of systemic ...

introduction basidiobolomycosis is a rare disease that, unlike other fungal infections, affects immunocompetent individuals. it is caused by an environmental saprophyte named the fungus basidiobolus ranarum. basidiobolomycosis usually appears as a subcutaneous infection. gi basidiobolomycosis is an emerging disease, and the colon is the most frequent involved part of the gi tract. case presenta...

BACKGROUND AND PURPOSE Detection of agents responsible for cutaneous mycosis may be effective in the prevention of fungal infections from environmental and animal sources. With this background in mind, in this study, we aimed to identify the distribution of cutaneous mycotic infections in patients referred to Imam Reza Hospital of Mashhad, Iran during 2000- 2011. MATERIALS AND METHODS In tota...