The individual and effects of interaction of nature (X) and concentration (Y) of disintegrant and the relative density (Z) on the mechanical and release properties of chloroquine phosphate tablets were studied using a 2 factorial experimental design. Water yam starch (“low” level) and corn starch (“high” level) were used as disintegrants at concentrations of 5.0% and 20.0% w/w. The mechanical p...

An efficient disintegrant is capable of breaking up a tablet in the smallest possible particles in the shortest time. Until now, comparative data on the efficacy of different disintegrants is based on dissolution studies or the disintegration time. Extending these approaches, this study introduces a method, which defines the evolution of fractal dimensions of tablets as surrogate parameter for ...

Leucaena (Leucaena leucocephala) seed gum (LSG) was evaluated for disintegrant action in lactose (soluble) based tablets containing ibuprofen, a relatively insoluble drug. The properties of tablets evaluated include weight uniformity, hardness, friability, disintegration time and in vitro dissolution (k, T 50 , A 30 ). LSG, at low concentration level (2% w/w), can be used as a disintegrant in t...

Effects of Phosphate Modified and Pregelatinized Sweet Potato Starches on Disintegrant Property Paracetamol Tablet FormulationsI. Jubril, J. Muazu, G. T. Mohammed

Crospovidone is a commonly used tablet disintegrant. However, the synthetic disintegrant has been known to be hygroscopic and high moisture content in crospovidone used could exert deleterious effects on tablets formulated with it. The objective of this study was to elicit a better understanding between crospovidone-water interaction and its effect on disintegrant performance. Moisture sorption...

The plantation, evolvement, phytochemical, pharmaceutical and pharmacological properties of Plantago ovata have been reviewed to reconnoiter the plant’s diverse properties. P. belonging family Plantaginaceae is a perennial plant native Mediterranean area, particularly Southern Europe, North Africa West Asia. It has variety medicinal effects as it frequently employed in medications for its featu...

The hydrophobicity of poorly soluble drugs can delay tablets disintegration. We probed here the influence different disintegrants on disintegration challenging hydrophobic formulations. Tablets containing diluents, hydrogenated vegetable oil and either sodium starch glycolate (SSG), croscarmellose (CCS) or crospovidone (XPVP) were prepared. time was tested immediately after storage at 40 °C 75%...